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PMID: 3039159 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The four classes of endogenous murine leukemia virus: structural relationships and potential for recombination.

Journal of virology ·Vol. 61 ·No. 9 ·1987-09-00 ·Pages 2659-69

Stoye JP, Coffin JM

Abstract

The process by which leukemogenic viruses are generated during the lifetime of certain strains of mice is poorly understood. We have therefore set out to define all the murine leukemia virus-related endogenous proviruses of HRS/J mice. We have cloned 34 different proviral fragments and their flanking cellular sequences. These have been characterized by restriction enzyme analysis, by fingerprinting in vitro-synthesized RNA, and by DNA sequencing. We conclude that all the proviruses can be assigned into one of four different classes: the previously characterized ecotropic, xenotropic, and polytropic viruses, as well as a new class we have termed modified polytropic viruses. The xenotropic, polytropic, and modified polytropic classes are closely related to one another, but as a group they differ considerably from the ecotropic class. Sequence analyses show that both polytropic and modified polytropic sequences can contribute env sequences to recombinant viruses.

MeSH Terms
Animals Biological Evolution Chromosome Deletion DNA, Viral/analysis Genes, Viral Leukemia Virus, Murine/classification,genetics Mice Recombination, Genetic Repetitive Sequences, Nucleic Acid
Chemicals
DNA, Viral
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Stoye J P
Coffin J M
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55 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.61.9.2659-2669.1987
Published
1987-09-00
Pages
2659-69
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC255766
Subset
IM
Grants
NCI NIH HHS · CA 24530 · United States
Databases
GENBANK
M17326, M17327
External Links
PubMed source DOI: 10.1128/JVI.61.9.2659-2669.1987 PMC Full Text View journal details
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