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PMID: 2987946 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

The alpha-spectrin gene is on chromosome 1 in mouse and man.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 82 ·No. 11 ·1985-06-00 ·Pages 3790-3

Huebner K, Palumbo AP, Isobe M, Kozak CA, Monaco S, Rovera G, Croce CM, Curtis PJ

Abstract

By using alpha-spectrin cDNA clones of murine and human origin and somatic cell hybrids segregating either mouse or human chromosomes, the gene for alpha-spectrin has been mapped to chromosome 1 in both species. This assignment of the mouse alpha-spectrin gene to mouse chromosome 1 by DNA hybridization strengthens the previous identification of the alpha-spectrin locus in mouse with the sph locus, which previously was mapped by linkage analysis to mouse chromosome 1, distal to the Pep-3 locus. By in situ hybridization to human metaphase chromosomes, the human alpha-spectrin gene has been localized to 1q22-1q25; interestingly, the locus for a non-Rh-linked form of elliptocytosis has been provisionally mapped to band 1q2 by family linkage studies.

MeSH Terms
Animals Chromosome Mapping Chromosomes, Human, 1-3 Cricetinae Cricetulus DNA Restriction Enzymes/metabolism Deoxyribonuclease HindIII Humans Karyotyping Mice Nucleic Acid Hybridization Spectrin/genetics
Chemicals
Spectrin DNA Restriction Enzymes Deoxyribonuclease HindIII
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Huebner K
Palumbo A P
Isobe M
Kozak C A
Monaco S
Rovera G
Croce C M
Curtis P J
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33 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.82.11.3790
Published
1985-06-00
Pages
3790-3
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC397873
Subset
IM
Grants
NCI NIH HHS · CA-10815 · United States
NCI NIH HHS · CA-16685 · United States
NCI NIH HHS · CA-21124 · United States
External Links
PubMed source DOI: 10.1073/pnas.82.11.3790 PMC Full Text View journal details
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