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PMID: 29748285 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

An anatomic transcriptional atlas of human glioblastoma.

Science (New York, N.Y.) ·Vol. 360 ·No. 6389 ·2018-00-11 ·Pages 660-663

Puchalski RB, Shah N, Miller J, Dalley R, Nomura SR, Yoon JG, Smith KA, Lankerovich M, Bertagnolli D, Bickley K, Boe AF, Brouner K, Butler S, Caldejon S, Chapin M, Datta S, Dee N, Desta T, Dolbeare T, Dotson N, Ebbert A, Feng D, Feng X, Fisher M, Gee G, Goldy J, Gourley L, Gregor BW, Gu G, Hejazinia N, Hohmann J, Hothi P, Howard R, Joines K, Kriedberg A, Kuan L, Lau C, Lee F, Lee H, Lemon T, Long F, Mastan N, Mott E, Murthy C, Ngo K, Olson E, Reding M, Riley Z, Rosen D, Sandman D, Shapovalova N, Slaughterbeck CR, Sodt A, Stockdale G, Szafer A, Wakeman W, Wohnoutka PE, White SJ, Marsh D, Rostomily RC, Ng L, Dang C, Jones A, Keogh B, Gittleman HR, Barnholtz-Sloan JS, Cimino PJ, Uppin MS, Keene CD, Farrokhi FR, Lathia JD, Berens ME, Iavarone A, Bernard A, Lein E, Phillips JW, Rostad SW, Cobbs C, Hawrylycz MJ, Foltz GD

Abstract

Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor's molecular and cellular landscapes are complex, and their relationships to histologic features routinely used for diagnosis are unclear. We present the Ivy Glioblastoma Atlas, an anatomically based transcriptional atlas of human glioblastoma that aligns individual histologic features with genomic alterations and gene expression patterns, thus assigning molecular information to the most important morphologic hallmarks of the tumor. The atlas and its clinical and genomic database are freely accessible online data resources that will serve as a valuable platform for future investigations of glioblastoma pathogenesis, diagnosis, and treatment.

MeSH Terms
Atlases as Topic Brain Neoplasms/genetics,pathology Databases, Genetic Gene Expression Profiling Glioblastoma/genetics,pathology Humans Prognosis
Authors & Affiliations
80 authors, click to expand affiliations / ORCID
Puchalski Ralph B ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA. mikeh@alleninstitute.org rbpuchalski@gmail.com nameeta.shah@gmail.com. | Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.
Shah Nameeta ORCID
Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA. mikeh@alleninstitute.org rbpuchalski@gmail.com nameeta.shah@gmail.com. | Mazumdar Shaw Center for Translational Research, Bangalore 560099, India.
Miller Jeremy
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Dalley Rachel
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Nomura Steve R ORCID
Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.
Yoon Jae-Guen ORCID
Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.
Smith Kimberly A
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Lankerovich Michael ORCID
Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.
Bertagnolli Darren ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Bickley Kris ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Boe Andrew F
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Brouner Krissy ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Butler Stephanie
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Caldejon Shiella
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Chapin Mike ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Datta Suvro
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Dee Nick ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Desta Tsega ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Dolbeare Tim
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Dotson Nadezhda ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Ebbert Amanda
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Feng David ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Feng Xu ORCID
Radia Inc., Lynnwood, WA 98036, USA.
Fisher Michael
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Gee Garrett
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Goldy Jeff ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Gourley Lindsey
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Gregor Benjamin W ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Gu Guangyu ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Hejazinia Nika ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Hohmann John
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Hothi Parvinder
Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.
Howard Robert
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Joines Kevin ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Kriedberg Ali
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Kuan Leonard
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Lau Chris
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Lee Felix ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Lee Hwahyung
Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.
Lemon Tracy
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Long Fuhui
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Mastan Naveed ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Mott Erika
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Murthy Chantal ORCID
Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.
Ngo Kiet
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Olson Eric
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Reding Melissa ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Riley Zack ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Rosen David
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Sandman David ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Shapovalova Nadiya ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Slaughterbeck Clifford R ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Sodt Andrew
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Stockdale Graham ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Szafer Aaron ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Wakeman Wayne
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Wohnoutka Paul E ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
White Steven J ORCID
White Marsh Forests, Seattle, WA 98119, USA.
Marsh Don ORCID
White Marsh Forests, Seattle, WA 98119, USA.
Rostomily Robert C
Department of Neurosurgery, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA. | Department of Neurological Surgery, Houston Methodist Hospital and Research Institute, Houston, TX 77030, USA.
Ng Lydia
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Dang Chinh
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Jones Allan
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Keogh Bart
Radia Inc., Lynnwood, WA 98036, USA.
Gittleman Haley R
Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Barnholtz-Sloan Jill S ORCID
Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Cimino Patrick J ORCID
Department of Pathology, Division of Neuropathology, University of Washington School of Medicine, Seattle, WA 98104, USA.
Uppin Megha S
Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad 500082, India.
Keene C Dirk ORCID
Department of Pathology, Division of Neuropathology, University of Washington School of Medicine, Seattle, WA 98104, USA.
Farrokhi Farrokh R ORCID
Virginia Mason Medical Center, Seattle, WA 98101, USA.
Lathia Justin D
Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.
Berens Michael E ORCID
TGen, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Iavarone Antonio
Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA. | Department of Neurology, Columbia University, New York, NY 10032, USA. | Department of Pathology, Columbia University, New York, NY 10032, USA.
Bernard Amy
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Lein Ed ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Phillips John W
Allen Institute for Brain Science, Seattle, WA 98109, USA.
Rostad Steven W ORCID
CellNetix, Seattle, WA 98122, USA.
Cobbs Charles
Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.
Hawrylycz Michael J ORCID
Allen Institute for Brain Science, Seattle, WA 98109, USA. mikeh@alleninstitute.org rbpuchalski@gmail.com nameeta.shah@gmail.com.
Foltz Greg D
Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.aaf2666
Email
mikeh@alleninstitute.org
rbpuchalski@gmail.com
nameeta.shah@gmail.com
Published
2018-00-11
Pages
660-663
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC6414061
Subset
IM
Grants
NCI NIH HHS · R01 CA136808 · United States
NCI NIH HHS · R01 CA179044 · United States
NCI NIH HHS · R01 CA178546 · United States
NCI NIH HHS · R01 CA190891 · United States
NCI NIH HHS · U54 CA193313 · United States
NINDS NIH HHS · R01 NS091251 · United States
NINDS NIH HHS · R01 NS061776 · United States
External Links
PubMed source DOI: 10.1126/science.aaf2666 PMC Full Text View journal details
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