Home LiteratureArticle Details
PMID: 25395464 Published · ppublish English Letter

MGMT methylation in glioblastoma: tale of the tail.

Neuro-oncology ·Vol. 17 ·No. 1 ·2015-01-00 ·Pages 167-8

Shah N, Schroeder B, Cobbs C

Abstract

暂无摘要

MeSH Terms
Antineoplastic Agents, Alkylating/therapeutic use DNA Methylation DNA Modification Methylases/genetics DNA Repair Enzymes/genetics Dacarbazine/analogs & derivatives,therapeutic use Glioblastoma/drug therapy,genetics Humans Kaplan-Meier Estimate Promoter Regions, Genetic Temozolomide Treatment Outcome Tumor Suppressor Proteins/genetics
Chemicals
Antineoplastic Agents, Alkylating Tumor Suppressor Proteins Dacarbazine DNA Modification Methylases MGMT protein, human DNA Repair Enzymes Temozolomide
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Shah Nameeta
The Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, Washington.
Schroeder Brett
The Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, Washington.
Cobbs Charles
The Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, Washington.
References (5)
5 references, click to expand
  1. Dose-dense temozolomide for newly diagnosed glioblastoma: a randomized phase III clinical trial.
    J Clin Oncol. 2013 Nov 10;31(32):4085-91 PMID: 24101040
  2. Comprehensive analysis of MGMT promoter methylation: correlation with MGMT expression and clinical response in GBM.
    PLoS One. 2011;6(1):e16146 PMID: 21249131
  3. Validation of real-time methylation-specific PCR to determine O6-methylguanine-DNA methyltransferase gene promoter methylation in glioma.
    J Mol Diagn. 2008 Jul;10(4):332-7 PMID: 18556773
  4. MS-MLPA: an attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas.
    Lab Invest. 2007 Oct;87(10):1055-65 PMID: 17700563
  5. MGMT gene silencing and benefit from temozolomide in glioblastoma.
    N Engl J Med. 2005 Mar 10;352(10):997-1003 PMID: 15758010
Article Info
Journal
Neuro-oncology
Abbr.
Neuro Oncol
ISSN
1523-5866
DOI
10.1093/neuonc/nou319
Published
2015-01-00
Epub
2014-00-13
Pages
167-8
Language
English
Region
England
NLM ID
100887420
PMCID
PMC4483058
Subset
IM
External Links
PubMed source DOI: 10.1093/neuonc/nou319 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2