Home LiteratureArticle Details
PMID: 29016836 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Comment

Putting "multiforme" back into glioblastoma: intratumoral transcriptome heterogeneity is a consequence of its complex morphology.

Neuro-oncology ·Vol. 19 ·No. 12 ·2017-00-29 ·Pages 1570-1571

Khagi S, Miller CR

Abstract

暂无摘要

Keywords
genomics glioblastoma heterogeneity histology transcriptome
MeSH Terms
Adult Brain Neoplasms Cues Glioblastoma Humans Transcriptome
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Khagi Simon
Division of Hematology/Oncology, Department of Medicine, Division of Neuro-oncology, Department of Neurosurgery, Lineberger Comprehensive Cancer Center, Division of Neuropathology, Department of Pathology and Laboratory Medicine, and Department of Neurology and Neurosciences Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Miller C Ryan
Division of Hematology/Oncology, Department of Medicine, Division of Neuro-oncology, Department of Neurosurgery, Lineberger Comprehensive Cancer Center, Division of Neuropathology, Department of Pathology and Laboratory Medicine, and Department of Neurology and Neurosciences Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
References (7)
7 references, click to expand
  1. Histologically defined intratumoral sequencing uncovers evolutionary cues into conserved molecular events driving gliomagenesis.
    Neuro Oncol. 2017 Nov 29;19(12 ):1599-1606 PMID: 28541485
  2. Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma.
    Science. 2014 Jan 10;343 (6167):189-193 PMID: 24336570
  3. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.
    Science. 2014 Jun 20;344(6190):1396-401 PMID: 24925914
  4. The somatic genomic landscape of glioblastoma.
    Cell. 2013 Oct 10;155(2):462-77 PMID: 24120142
  5. Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics.
    Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4009-14 PMID: 23412337
  6. Hallmarks of cancer: the next generation.
    Cell. 2011 Mar 4;144(5):646-74 PMID: 21376230
  7. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.
    Cancer Cell. 2010 Jan 19;17(1):98-110 PMID: 20129251
Article Info
Journal
Neuro-oncology
Abbr.
Neuro Oncol
ISSN
1523-5866
DOI
10.1093/neuonc/nox131
Published
2017-00-29
Pages
1570-1571
Language
English
Region
England
NLM ID
100887420
PMCID
PMC5716077
Subset
IM
Grants
NCI NIH HHS · R01 CA204136 · United States
Corrections
CommentOn
PMID: 28541485
External Links
PubMed source DOI: 10.1093/neuonc/nox131 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2