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PMID: 29019985 Published · ppublish English Historical Article Journal Article Research Support, Non-U.S. Gov't Review

DNA sequencing at 40: past, present and future.

Nature ·Vol. 550 ·No. 7676 ·2017-00-19 ·Pages 345-353

Shendure J, Balasubramanian S, Church GM, Gilbert W, Rogers J, Schloss JA, Waterston RH

Abstract

This review commemorates the 40th anniversary of DNA sequencing, a period in which we have already witnessed multiple technological revolutions and a growth in scale from a few kilobases to the first human genome, and now to millions of human and a myriad of other genomes. DNA sequencing has been extensively and creatively repurposed, including as a 'counter' for a vast range of molecular phenomena. We predict that in the long view of history, the impact of DNA sequencing will be on a par with that of the microscope.

MeSH Terms
Animals Genomics History, 20th Century History, 21st Century Humans Metagenome/genetics Microscopy Sequence Analysis, DNA/history,methods,trends
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Shendure Jay
Department of Genome Sciences, University of Washington, Seattle, Washington, USA. | Howard Hughes Medical Institute, Seattle, Washington, USA.
Balasubramanian Shankar
Department of Chemistry, University of Cambridge, Cambridge, UK. | Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Church George M
The Wyss Institute & Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Gilbert Walter
Department of Molecular and Cellular Biology, Harvard University, Cambridge Massachusetts, USA.
Rogers Jane
International Wheat Genome Sequencing Consortium, Little Eversden, Cambridge, UK.
Schloss Jeffery A
National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Waterston Robert H
Department of Genome Sciences, University of Washington, Seattle, Washington, USA.
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature24286
Published
2017-00-19
Epub
2017-00-11
Pages
345-353
Language
English
Region
England
NLM ID
0410462
Subset
IM
Corrections
ErratumIn
PMID: 30948799
External Links
PubMed source DOI: 10.1038/nature24286 View journal details
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