A new hypervariable marker for the human alpha-globin gene cluster.

American journal of human genetics ·Vol. 43 ·No. 3 ·1988-09-00 ·Pages 249-56

Jarman AP, Higgs DR

Abstract

We have located a highly polymorphic region of DNA approximately 100 kb upstream of the human alpha-globin genes (the alpha-globin 5' hypervariable region; 5'HVR). The element responsible is a minisatellite sequence comprising a variable copy number tandem repeat array of a G/C-rich 57-bp sequence. This increases the number of minisatellite elements in the vicinity of the alpha-globin genes to five, all of which share a region of sequence identity, thus raising questions concerning the distribution and origins of such tandem repeat sequences. The 5'HVR is highly polymorphic and, together with other hypervariable regions at this locus, provides a valuable genetic marker on the short arm of chromosome 16.

MeSH Terms

Base Sequence Chromosomes, Human, Pair 16 Cloning, Molecular DNA, Satellite Genetics, Population Globins/genetics Humans Molecular Sequence Data Multigene Family Polymorphism, Restriction Fragment Length

Chemicals

DNA, Satellite Globins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Jarman A P

University of Oxford, John Radcliffe Hospital, Nuffield Department of Clinical Medicine, Headington, England.

Higgs D R

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26 references, click to expand

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Article Info

Journal

American journal of human genetics

Abbr.

Am J Hum Genet

ISSN

0002-9297

Published

1988-09-00

Pages

249-56

Language

English

Region

United States

NLM ID

0370475

PMCID

PMC1715380

Subset

External Links

PubMed source PMC Full Text View journal details

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A new hypervariable marker for the human alpha-globin gene cluster.

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