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PMID: 2889665 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Modulation of granulocyte functions by bacterial exotoxin and endotoxins.

Immunology ·Vol. 62 ·No. 3 ·1987-11-00 ·Pages 363-71

Bremm KD, König W, Thelestam M, Alouf JE

Abstract

The modulation of granulocyte functions by bacterial exotoxins (Streptolysin O, alveolysin, theta toxin) and endotoxins from salmonella and lipid A is described here. Incubation of polymorphonuclear granulocytes with thiol-activated toxins resulted in an increased leukotriene generation. Toxin-pretreated PMNs revealed an increased omega oxidation of LTB4, which may explain why toxin-stimulated cells release more LTC4 than LTB4. Furthermore, toxin-pretreated PMNs showed a decreased leukotriene generation on subsequent stimulation with the Ca-ionophore A 23187 or opsonized zymosan.

MeSH Terms
Bacterial Proteins Bacterial Toxins/immunology Clostridium perfringens Endotoxins/immunology Exotoxins/immunology Hemolysin Proteins/immunology Humans Leukotriene B4/metabolism Leukotriene E4 Lipid A/immunology Neutrophils/drug effects,immunology Organic Chemicals SRS-A/analogs & derivatives,metabolism Salmonella Streptolysins/immunology
Chemicals
Bacterial Proteins Bacterial Toxins Endotoxins Exotoxins Hemolysin Proteins Lipid A Organic Chemicals SRS-A Streptolysins streptolysin O Leukotriene B4 Clostridium perfringens theta-toxin Leukotriene E4 alveolysin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bremm K D
Lehrstuhl für Medizinische Mikrobiologie und Immunologie, AG Infektabwehr, Ruhr-Universität Bochum, West Germany.
König W
Thelestam M
Alouf J E
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1987-11-00
Pages
363-71
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1454132
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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