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PMID: 7298179 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Effects of pneumolysin on human polymorphonuclear leukocytes and platelets.

Infection and immunity ·Vol. 34 ·No. 1 ·1981-10-00 ·Pages 171-6

Johnson MK, Boese-Marrazzo D, Pierce WA

Abstract

Pneumolysin was bound by human polymorphonuclear leukocytes in a reaction which occurred very rapidly at 0 degrees C. Low concentrations of pneumolysin were found to stimulate leukocyte migration and lysosomal enzyme secretion. At increasing lysin levels, inhibition of spontaneous migration and chemotaxis, cell death, and lysis were observed. Pneumolysin was also found to lyse platelets and to activate serum to become chemotactic.

MeSH Terms
Bacterial Proteins Blood Platelets/physiology Cell Adhesion Cell Aggregation Cell Survival Chemotaxis, Leukocyte Humans Muramidase/metabolism Neutrophils/physiology Streptolysins/metabolism,pharmacology
Chemicals
Bacterial Proteins Streptolysins plY protein, Streptococcus pneumoniae Muramidase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Johnson M K
Boese-Marrazzo D
Pierce W A
References (10)
10 references, click to expand
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    Biochim Biophys Acta. 1979 Sep 21;556(2):278-91 PMID: 534628
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    Infect Immun. 1980 Jan;27(1):97-101 PMID: 7358434
  9. STUDIES ON LYSOSOMES. III. THE EFFECTS OF STREPTOLYSINS O AND S ON THE RELEASE OF ACID HYDROLASES FROM A GRANULAR FRACTION OF RABBIT LIVER.
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.34.1.171-176.1981
Published
1981-10-00
Pages
171-6
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC350839
Subset
IM
Grants
NEI NIH HHS · EY 00424 · United States
External Links
PubMed source DOI: 10.1128/iai.34.1.171-176.1981 PMC Full Text View journal details
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