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PMID: 6490085 Published · ppublish English Journal Article

Generation of slow-reacting substance (leukotrienes) by endotoxin and lipid A from human polymorphonuclear granulocytes.

Immunology ·Vol. 53 ·No. 2 ·1984-10-00 ·Pages 299-305

Bremm KD, König W, Spur B, Crea A, Galanos C

Abstract

Leukotrienes were released from human polymorphonuclear granulocytes on incubation with endotoxins and lipid A. The analysis was performed by their smooth muscle contracting properties, reversed phase high-pressure liquid chromatography and radioimmunoassay for leukotrienes C4 and D4. The active component of the lipopolysaccharides seems to be the lipid A portion.

MeSH Terms
Biological Assay Chromatography, High Pressure Liquid Endotoxins/pharmacology Humans Lipid A/pharmacology Neutrophils/drug effects,metabolism SRS-A/analysis,biosynthesis Salmonella
Chemicals
Endotoxins Lipid A SRS-A
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Bremm K D
König W
Spur B
Crea A
Galanos C
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22 references, click to expand
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1984-10-00
Pages
299-305
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1454833
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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