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PMID: 2877933 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Regional localisations and linkage relationships of seven RFLPs and myotonic dystrophy on chromosome 19.

Human genetics ·Vol. 74 ·No. 3 ·1986-11-00 ·Pages 262-6

Shaw DJ, Meredith AL, Sarfarazi M, Harley HG, Huson SM, Brook JD, Bufton L, Litt M, Mohandas T, Harper PS

Abstract

We have studied the genetic linkage relationships of seven DNA polymorphisms on chromosome 19, with each other and with the myotonic dystrophy locus. The DNA sequences were localised to various regions of the chromosome using translocations in somatic cell hybrids. These results provide the basis for a linkage map of most of chromosome 19, and suggest that the myotonic dystrophy locus is close to the centromere.

MeSH Terms
Animals Chromosome Mapping Chromosomes, Human, Pair 19/ultrastructure DNA Female Genetic Linkage Genetic Markers Humans Hybrid Cells/analysis Male Mice Myotonic Dystrophy/diagnosis,genetics Polymorphism, Genetic Polymorphism, Restriction Fragment Length Translocation, Genetic
Chemicals
Genetic Markers DNA
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Shaw D J
Meredith A L
Sarfarazi M
Harley H G
Huson S M
Brook J D
Bufton L
Litt M
Mohandas T
Harper P S
References (16)
16 references, click to expand
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00282545
Published
1986-11-00
Pages
262-6
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00282545 View journal details
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