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PMID: 3857215 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Assignment of human ferritin genes to chromosomes 11 and 19q13.3----19qter.

Human genetics ·Vol. 69 ·No. 4 ·1985-00-00 ·Pages 371-4

Worwood M, Brook JD, Cragg SJ, Hellkuhl B, Jones BM, Perera P, Roberts SH, Shaw DJ

Abstract

Extracts of hamster-human and mouse-human hybrids, some with translocations involving chromosome 19, have been assayed for both human spleen ferritin (rich in L subunits) and human heart ferritin (rich in H subunits). Hybrid lines retaining part of the long arm of chromosome 19 including the region 19q13.3----19qter produced human "L" type ferritin. This confirms the previous assignment of the "ferritin gene" to chromosome 19 (Caskey et al. 1983). However, lines retaining chromosome 11 were found to contain human "H" type ferritin suggesting that the gene for the "H" subunit is on this chromosome. The presence of chromosome 6 was not necessary for the expression of either "H" or "L" type human ferritin. It thus seems unlikely that the gene for idiopathic haemochromatosis is a ferritin gene.

MeSH Terms
Animals Cell Line Chromosome Banding Chromosome Mapping Chromosomes, Human, 19-20 Chromosomes, Human, 6-12 and X Cricetinae Ferritins/genetics Genetic Markers Humans Hybrid Cells Karyotyping Mice Myocardium/metabolism
Chemicals
Genetic Markers Ferritins
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Worwood M
Brook J D
Cragg S J
Hellkuhl B
Jones B M
Perera P
Roberts S H
Shaw D J
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27 references, click to expand
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00291657
Published
1985-00-00
Pages
371-4
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00291657 View journal details
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