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PMID: 2991117 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The apolipoprotein CII gene: subchromosomal localisation and linkage to the myotonic dystrophy locus.

Human genetics ·Vol. 70 ·No. 3 ·1985-00-00 ·Pages 271-3

Shaw DJ, Meredith AL, Sarfarazi M, Huson SM, Brook JD, Myklebost O, Harper PS

Abstract

The human apolipoprotein CII gene probe detects a restriction fragment length polymorphism located on chromosome 19. We have investigated the linkage of this polymorphism to the myotonic dystrophy locus in families. The two loci are closely linked with a maximum Lod score of 7.877 at 4% recombination. The close linkage and informativeness of the APOC2 polymorphism suggest that this probe may be of use for presymptomatic diagnosis of the myotonic dystrophy gene. The APOC2 gene was localised to the region 19p13-19q13 using somatic cell hybrids, providing further evidence that the myotonic dystrophy locus is situated in the central region of chromosome 19.

MeSH Terms

Animals Apolipoprotein C-II Apolipoproteins C/genetics Chromosome Mapping Chromosomes, Human, 19-20 DNA Restriction Enzymes Female Genetic Markers Humans Hybrid Cells Lod Score Male Myotonic Dystrophy/genetics Polymorphism, Genetic

Chemicals

Apolipoprotein C-II Apolipoproteins C Genetic Markers DNA Restriction Enzymes

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Shaw D J

Meredith A L

Sarfarazi M

Huson S M

Brook J D

Myklebost O

Harper P S

References (12)

12 references, click to expand

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The locus for apolipoprotein CII is closely linked to the apolipoprotein E locus on chromosome 19 in man.
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The isolation and characterization of cDNA clones for human apolipoprotein CII.
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Localisation of genetic markers and orientation of the linkage group on chromosome 19.
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The locus for apolipoprotein E (apoE) is close to the Lutheran (Lu) blood group locus on chromosome 19.
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Genetic linkage confirmed between the locus for myotonic dystrophy and the ABH-secretion and Lutheran blood group loci.
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Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00273455

Published

1985-00-00

Pages

271-3

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00273455 View journal details

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The apolipoprotein CII gene: subchromosomal localisation and linkage to the myotonic dystrophy locus.

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