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PMID: 2825194 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 84 ·No. 23 ·1987-12-00 ·Pages 8535-9

Carroll MC, Katzman P, Alicot EM, Koller BH, Geraghty DE, Orr HT, Strominger JL, Spies T

Abstract

The tumor necrosis factor (TNF) alpha and beta gene pair has been linked in the human major histocompatibility complex to HLA-B, HLA-C, and, tentatively, HLA-E and HLA-A on one side and to the class III complement/steroid 21-hydroxylase gene cluster on the other by pulsed-field gel electrophoresis. The TNF genes are located 200 kilobases (kb) centromeric of HLA-B and about 350 kb telomeric of the class III cluster. Together with previous data on the linkage and structures of the class II and class III regions, a restriction map of the entire human major histocompatibility complex of about 3500 kb has been prepared.

MeSH Terms
Chromosome Mapping Chromosomes, Human, Pair 6 Complement System Proteins/genetics DNA Restriction Enzymes Genetic Linkage HLA Antigens/genetics HLA-D Antigens/genetics Humans Major Histocompatibility Complex Tumor Necrosis Factor-alpha/genetics
Chemicals
HLA Antigens HLA-D Antigens Tumor Necrosis Factor-alpha Complement System Proteins DNA Restriction Enzymes
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Carroll M C
Department of Pediatrics, Harvard Medical School, Boston, MA 02115.
Katzman P
Alicot E M
Koller B H
Geraghty D E
Orr H T
Strominger J L
Spies T
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.84.23.8535
Published
1987-12-00
Pages
8535-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC299579
Subset
IM
Grants
NIAID NIH HHS · AI-20182 · United States
NIDDK NIH HHS · DK-30241 · United States
External Links
PubMed source DOI: 10.1073/pnas.84.23.8535 PMC Full Text View journal details
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