Home LiteratureArticle Details
PMID: 2999289 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

The Journal of experimental medicine ·Vol. 162 ·No. 6 ·1985-12-01 ·Pages 2163-8

Dayer JM, Beutler B, Cerami A

Abstract

Cachectin/TNF (tumor necrosis factor), an endotoxin-induced murine macrophage hormone implicated in the pathogenesis of cachexia and shock, has been found capable of stimulating collagenase and prostaglandin E2 (PGE2) production by isolated human synovial cells and dermal fibroblasts. This bioactivity associated with cachectin is comparable to that observed with the monokine interleukin 1 (IL-1), previously suggested as the major mediator of proteolysis. The ability of cachectin/TNF to stimulate collagenase and PGE2 production suggests that it may play a role in tissue destruction and remodelling, as these processes occur in inflammatory diseases.

MeSH Terms
Animals Dinoprostone Fibroblasts/enzymology,metabolism Glycoproteins/physiology Humans Interferon Type I/pharmacology Interleukin-1/physiology Mice Microbial Collagenase/biosynthesis Monokines Prostaglandins E/biosynthesis Proteins/physiology Recombinant Proteins Skin Synovial Membrane/cytology,enzymology,metabolism Tumor Necrosis Factor-alpha
Chemicals
Glycoproteins Interferon Type I Interleukin-1 Monokines Prostaglandins E Proteins Recombinant Proteins Tumor Necrosis Factor-alpha Microbial Collagenase Dinoprostone
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dayer J M
Beutler B
Cerami A
References (20)
20 references, click to expand
  1. Metabolic response to infection.
    Annu Rev Med. 1975;26:9-20 PMID: 1096783
  2. Identity of tumour necrosis factor and the macrophage-secreted factor cachectin.
    Nature. 1985 Aug 8-14;316(6028):552-4 PMID: 2993897
  3. An endotoxin-induced serum factor that causes necrosis of tumors.
    Proc Natl Acad Sci U S A. 1975 Sep;72(9):3666-70 PMID: 1103152
  4. Participation of monocyte-macrophages and lymphocytes in the production of a factor that stimulates collagenase and prostaglandin release by rheumatoid synovial cells.
    J Clin Invest. 1979 Nov;64(5):1386-92 PMID: 227933
  5. Purification of a factor from human blood monocyte-macrophages which stimulates the production of collagenase and prostaglandin E2 by cells cultured from rheumatoid synovial tissues.
    FEBS Lett. 1981 Feb 23;124(2):253 PMID: 6262122
  6. Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1).
    Proc Natl Acad Sci U S A. 1981 Apr;78(4):2474-7 PMID: 6264478
  7. Arachidonic acid, prostaglandin E2 and F2 alpha influence rates of protein turnover in skeletal and cardiac muscle.
    J Biol Chem. 1982 Feb 25;257(4):1632-8 PMID: 6799511
  8. Stimulation of muscle protein degradation and prostaglandin E2 release by leukocytic pyrogen (interleukin-1). A mechanism for the increased degradation of muscle proteins during fever.
    N Engl J Med. 1983 Mar 10;308(10):553-8 PMID: 6402699
  9. Interleukin-1.
    Rev Infect Dis. 1984 Jan-Feb;6(1):51-95 PMID: 6369481
  10. Induction of human interleukin 1 mRNA measured by collagenase- and prostaglandin E2-stimulating activity in rheumatoid synovial cells.
    Eur J Immunol. 1984 Oct;14(10):898-901 PMID: 6092094
  11. Cloning and expression of murine interleukin-1 cDNA in Escherichia coli.
    Nature. 1984 Nov 29-Dec 5;312(5993):458-62 PMID: 6209582
  12. Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.
    Nature. 1984 Dec 20-1985 Jan 2;312(5996):724-9 PMID: 6392892
  13. Purification of rabbit tumor necrosis factor.
    FEBS Lett. 1985 Jan 28;180(2):203-6 PMID: 3967764
  14. Monokines and the metabolic pathophysiology of septic shock.
    Fed Proc. 1985 Feb;44(2):300-4 PMID: 3881289
  15. Lipopolysaccharide-treated RAW 264.7 cells produce a mediator that inhibits lipoprotein lipase in 3T3-L1 cells.
    J Immunol. 1985 Mar;134(3):1673-5 PMID: 3968430
  16. Human tumor necrosis factor. Production, purification, and characterization.
    J Biol Chem. 1985 Feb 25;260(4):2345-54 PMID: 3871770
  17. Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells.
    J Exp Med. 1985 May 1;161(5):984-95 PMID: 3872925
  18. A macrophage factor inhibits adipocyte gene expression: an in vitro model of cachexia.
    Science. 1985 Aug 30;229(4716):867-9 PMID: 3839597
  19. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin.
    Science. 1985 Aug 30;229(4716):869-71 PMID: 3895437
  20. Prostaglandin-stimulated bone resorption by rheumatoid synovia. A possible mechanism for bone destruction in rheumatoid arthritis.
    J Clin Invest. 1975 Nov;56(5):1181-8 PMID: 1184744
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.162.6.2163
Published
1985-12-01
Pages
2163-8
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2187983
Subset
IM
Grants
NIADDK NIH HHS · AM01314 · United States
External Links
PubMed source DOI: 10.1084/jem.162.6.2163 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2