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PMID: 2821491 Published · ppublish English Journal Article

Potential secondary and tertiary structure in the genomic RNA of foot and mouth disease virus.

Nucleic acids research ·Vol. 15 ·No. 17 ·1987-09-11 ·Pages 7067-79

Clarke BE, Brown AL, Currey KM, Newton SE, Rowlands DJ, Carroll AR

Abstract

The nucleotide sequence of the 5' untranslated region of foot and mouth disease virus (FMDV), serotype A10 has been determined. This completes the first total genomic sequence for any one serotype of FMDV. Analysis of the sequence to the 3' side of the poly (C) tract reveals the presence of a 24 nucleotide repeated motif which has homologies with a sequence located upstream of the transcriptional initiation site from several mammalian fibrinogen genes. The function of this element in FMDV is unclear. However, computer analysis of this region predicts the presence of a high degree of secondary and tertiary structure in which these repeats form an important part. The implications of these predictions are discussed.

MeSH Terms
Aphthovirus/genetics Base Sequence Computer Simulation Genes, Viral Macromolecular Substances Models, Molecular Molecular Sequence Data Nucleic Acid Conformation RNA, Viral/genetics
Chemicals
Macromolecular Substances RNA, Viral
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Clarke B E
Wellcome Biotechnology Limited, Pirbright, Surrey, UK.
Brown A L
Currey K M
Newton S E
Rowlands D J
Carroll A R
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30 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/15.17.7067
Published
1987-09-11
Pages
7067-79
Language
English
Region
England
NLM ID
0411011
PMCID
PMC306193
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/15.17.7067 PMC Full Text View journal details
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