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PMID: 6264400 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Nucleotide sequence and corresponding amino acid sequence of the gene for the major antigen of foot and mouth disease virus.

Nucleic acids research ·Vol. 9 ·No. 8 ·1981-04-24 ·Pages 1919-31

Kurz C, Forss S, Küpper H, Strohmaier K, Schaller H

Abstract

A segment of 1160 nucleotides of the FMDV genome has been sequenced using three overlapping fragments of cloned cDNA from FMDV strain O1K. This sequence contains the coding sequence for the viral capsid protein VP1 as shown by its homology to known and newly determined amino acid sequences from this man antigenic polypeptide of the FMDV virion. The structural gene for VP1 comprises 639 nucleotides which specify a sequence of 213 amino acids for the VP1 protein. The coding sequence is not flanked by start and stop codons which is consistent with the mode of biosynthesis of VP1 by post-translational processing of a polyprotein precursor.

MeSH Terms
Amino Acid Sequence Antigens, Viral/genetics Aphthovirus/genetics Base Sequence Cloning, Molecular Codon DNA Restriction Enzymes DNA, Recombinant DNA, Viral/genetics Genes
Chemicals
Antigens, Viral Codon DNA, Recombinant DNA, Viral DNA Restriction Enzymes
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Kurz C
Forss S
Küpper H
Strohmaier K
Schaller H
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22 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/9.8.1919
Published
1981-04-24
Pages
1919-31
Language
English
Region
England
NLM ID
0411011
PMCID
PMC326812
Subset
IM
Databases
GENBANK
J02182, V01131
External Links
PubMed source DOI: 10.1093/nar/9.8.1919 PMC Full Text View journal details
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