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PMID: 27383982 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The microbiota in adaptive immune homeostasis and disease.

Nature ·Vol. 535 ·No. 7610 ·2016-00-07 ·Pages 75-84

Honda K, Littman DR

Abstract

In the mucosa, the immune system's T cells and B cells have position-specific phenotypes and functions that are influenced by the microbiota. These cells play pivotal parts in the maintenance of immune homeostasis by suppressing responses to harmless antigens and by enforcing the integrity of the barrier functions of the gut mucosa. Imbalances in the gut microbiota, known as dysbiosis, can trigger several immune disorders through the activity of T cells that are both near to and distant from the site of their induction. Elucidation of the mechanisms that distinguish between homeostatic and pathogenic microbiota-host interactions could identify therapeutic targets for preventing or modulating inflammatory diseases and for boosting the efficacy of cancer immunotherapy.

MeSH Terms
Animals Autoimmunity B-Lymphocytes/immunology Disease Dysbiosis/immunology,microbiology Gastrointestinal Microbiome/immunology Homeostasis Humans Inflammation/immunology,microbiology,therapy Intestinal Mucosa/immunology,microbiology Neoplasms/immunology,therapy Skin/immunology,microbiology T-Lymphocytes/immunology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Honda Kenya
Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan. | RIKEN Center for Integrative Medical Sciences, Tsurumi, Yokohama, Kanagawa 230-0045, Japan. | AMED-CREST, Chiyoda, Tokyo 100-0004, Japan.
Littman Dan R
The Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA. | The Howard Hughes Medical Institute, New York University School of Medicine, New York, New York 10016, USA.
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature18848
Published
2016-00-07
Pages
75-84
Language
English
Region
England
NLM ID
0410462
Subset
IM
Grants
Howard Hughes Medical Institute · United States
External Links
PubMed source DOI: 10.1038/nature18848 View journal details
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