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PMID: 23103985 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

New concepts in the generation and functions of IgA.

Nature reviews. Immunology ·Vol. 12 ·No. 12 ·2012-12-00 ·Pages 821-32

Pabst O

Abstract

The intestinal mucosa contains the largest population of antibody-secreting plasma cells in the body, and in humans several grams of secretory immunoglobulin A (SIgA) are released into the intestine each day. In the gut lumen, SIgA serves as a first-line barrier that protects the epithelium from pathogens and toxins. Recently, next-generation sequencing has revolutionized our understanding of the nature of the intestinal microbiota and has also shed new light on the important roles of SIgA in the regulation of host-commensal homeostasis. Here, I discuss pathways of IgA induction in the context of SIgA specificity and function.

MeSH Terms
Amino Acid Sequence Animals Gastrointestinal Tract/immunology,microbiology Immunoglobulin A, Secretory/immunology Lymphoid Tissue/immunology Metagenome Mice Models, Immunological Molecular Sequence Data Plasma Cells/immunology
Chemicals
Immunoglobulin A, Secretory
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Pabst Oliver
Institute of Immunology, Hannover Medical School, Carl-Neuberg Strae 1, 30625 Hannover, Germany. Pabst.Oliver@MHHannover.de
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri3322
Email
pabst.oliver@mhhannover.de
Published
2012-12-00
Epub
2012-00-29
Pages
821-32
Language
English
Region
England
NLM ID
101124169
Subset
IM
External Links
PubMed source DOI: 10.1038/nri3322 View journal details
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