Abstract
Despite tremendous progress in understanding the nature of the immune system, the full diversity of an organism's antibody repertoire is unknown. We used high-throughput sequencing of the variable domain of the antibody heavy chain from 14 zebrafish to analyze VDJ usage and antibody sequence. Zebrafish were found to use between 50 and 86% of all possible VDJ combinations and shared a similar frequency distribution, with some correlation of VDJ patterns between individuals. Zebrafish antibodies retained a few thousand unique heavy chains that also exhibited a shared frequency distribution. We found evidence of convergence, in which different individuals made the same antibody. This approach provides insight into the breadth of the expressed antibody repertoire and immunological diversity at the level of an individual organism.
MeSH Terms
Animals
Antibodies/genetics
Antibody Diversity
Base Sequence
Complementarity Determining Regions/genetics
Computational Biology
Female
Gene Library
Genes, Immunoglobulin Heavy Chain
Immunoglobulin Heavy Chains/genetics
Immunoglobulin Joining Region/genetics
Immunoglobulin M/genetics
Male
Molecular Sequence Data
Recombination, Genetic
Sequence Analysis, DNA
VDJ Exons
Zebrafish/genetics,immunology
Chemicals
Antibodies
Complementarity Determining Regions
Immunoglobulin Heavy Chains
Immunoglobulin Joining Region
Immunoglobulin M
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Weinstein Joshua A
Biophysics Program, Stanford University, Stanford, CA 94305, USA.
Jiang Ning
White Richard A
Fisher Daniel S
Quake Stephen R
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