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PMID: 21217761 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Eosinophils are required for the maintenance of plasma cells in the bone marrow.

Nature immunology ·Vol. 12 ·No. 2 ·2011-02-00 ·Pages 151-9

Chu VT, Fröhlich A, Steinhauser G, Scheel T, Roch T, Fillatreau S, Lee JJ, Löhning M, Berek C

Abstract

Plasma cells are of crucial importance for long-term immune protection. It is thought that long-lived plasma cells survive in specialized niches in the bone marrow. Here we demonstrate that bone marrow eosinophils localized together with plasma cells and were the key providers of plasma cell survival factors. In vitro, eosinophils supported the survival of plasma cells by secreting the proliferation-inducing ligand APRIL and interleukin-6 (IL-6). In eosinophil-deficient mice, plasma cell numbers were much lower in the bone marrow both at steady state and after immunization. Reconstitution experiments showed that eosinophils were crucial for the retention of plasma cells in the bone marrow. Moreover, depletion of eosinophils induced apoptosis in long-lived bone marrow plasma cells. Our findings demonstrate that the long-term maintenance of plasma cells in the bone marrow requires eosinophils.

MeSH Terms
Adoptive Transfer Animals Antigens, Differentiation/biosynthesis Apoptosis/immunology Blood Component Removal Bone Marrow/immunology,pathology Cell Survival/immunology Cells, Cultured Eosinophils/immunology,metabolism,pathology Immunologic Memory Interleukin-6/immunology,metabolism Mice Mice, Inbred BALB C Plasma Cells/cytology,immunology,metabolism Tumor Necrosis Factor Ligand Superfamily Member 13/immunology,metabolism
Chemicals
Antigens, Differentiation Interleukin-6 Tumor Necrosis Factor Ligand Superfamily Member 13 monocyte-macrophage differentiation antigen
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Chu Van Trung
Deutsches Rheuma-Forschungszentrum, Institut der Leibniz-Gemeinschaft, Berlin, Germany.
Fröhlich Anja
Steinhauser Gudrun
Scheel Tobias
Roch Toralf
Fillatreau Simon
Lee James J
Löhning Max
Berek Claudia
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Article Info
Journal
Nature immunology
Abbr.
Nat Immunol
ISSN
1529-2916
Published
2011-02-00
Epub
2011-00-09
Pages
151-9
Language
English
Region
United States
NLM ID
100941354
Subset
IM
Corrections
CommentIn
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