Abstract
The mammalian gastrointestinal tract contains a large and diverse population of commensal bacteria and is also one of the primary sites of exposure to pathogens. How the immune system perceives commensals in the context of mucosal infection is unclear. Here, we show that during a gastrointestinal infection, tolerance to commensals is lost, and microbiota-specific T cells are activated and differentiate to inflammatory effector cells. Furthermore, these T cells go on to form memory cells that are phenotypically and functionally consistent with pathogen-specific T cells. Our results suggest that during a gastrointestinal infection, the immune response to commensals parallels the immune response against pathogenic microbes and that adaptive responses against commensals are an integral component of mucosal immunity.
MeSH Terms
Acute Disease
Animals
Bacteria/immunology
Bacterial Translocation
CD4-Positive T-Lymphocytes/immunology
Flagellin/immunology
Gastrointestinal Tract/immunology,microbiology,parasitology
Immunity, Mucosal
Immunologic Memory
Intestinal Diseases, Parasitic/immunology,parasitology
Intestinal Mucosa/microbiology,parasitology
Lymphocyte Activation
Metagenome/immunology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Th1 Cells/immunology
Time Factors
Toxoplasma/immunology,physiology
Toxoplasmosis, Animal/immunology,parasitology
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Hand Timothy W
Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA.
Dos Santos Liliane M
Bouladoux Nicolas
Molloy Michael J
Pagán Antonio J
Pepper Marion
Maynard Craig L
Elson Charles O
Belkaid Yasmine
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