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PMID: 19707762 Published · ppublish English Journal Article Review

The mucosal firewalls against commensal intestinal microbes.

Seminars in immunopathology ·Vol. 31 ·No. 2 ·2009-07-00 ·Pages 145-9

Macpherson AJ, Slack E, Geuking MB, McCoy KD

Abstract

Mammals coexist with an extremely dense microbiota in the lower intestine. Despite the constant challenge of small numbers of microbes penetrating the intestinal surface epithelium, it is very unusual for these organisms to cause disease. In this review article, we present the different mucosal firewalls that contain and allow mutualism with the intestinal microbiota.

MeSH Terms
Animals Host-Pathogen Interactions/immunology Humans Intestinal Diseases/immunology,microbiology Intestinal Mucosa/immunology,microbiology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Macpherson Andrew J
DKF, Maurice Müller Laboratories, Department of Visceral Surgery and Medicine, University of Bern, Room G801, Bern, Switzerland. andrew.macpherson@insel.ch
Slack Emma
Geuking Markus B
McCoy Kathy D
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Article Info
Journal
Seminars in immunopathology
Abbr.
Semin Immunopathol
ISSN
1863-2300
DOI
10.1007/s00281-009-0174-3
Email
andrew.macpherson@insel.ch
Published
2009-07-00
Epub
2009-00-26
Pages
145-9
Language
English
Region
Germany
NLM ID
101308769
Subset
IM
External Links
PubMed source DOI: 10.1007/s00281-009-0174-3 View journal details
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