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PMID: 272670 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Demonstration of biological activity of brain gastrin-like peptidic material in the human: its relationship with the COOH-terminal octapeptide of cholecystokinin.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 1 ·1978-01-00 ·Pages 524-8

Robberecht P, Deschodt-Lanckman M, Vanderhaeghen JJ

Abstract

The previously described peptide material that reacts with antibodies to gastrin and is found in the central nervous system of various vertebrates is present in only the 100,000 X g pellet of postmortem human cerebral cortical grey matter. This immunoreactive material, extractable in boiling water, is biologically active on rat pancreatic preparations. On the basis of size, charge, immunological specificity, and patterns of biological activity, most of this material is closely related to the COOH-terminal octapeptide of cholecystokinin in its complete, sulfated biologically active form.

MeSH Terms

Adenylyl Cyclases/metabolism Amylases/metabolism Animals Binding, Competitive Brain Chemistry Ceruletide/metabolism Cholecystokinin/immunology,metabolism Gastrins/immunology,metabolism,pharmacology Humans Pancreas/enzymology Peptide Fragments/immunology Rats

Chemicals

Gastrins Peptide Fragments Ceruletide Cholecystokinin Amylases Adenylyl Cyclases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Robberecht P

Deschodt-Lanckman M

Vanderhaeghen J J

References (24)

24 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.75.1.524

Published

1978-01-00

Pages

524-8

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC411283

Subset

External Links

PubMed source DOI: 10.1073/pnas.75.1.524 PMC Full Text View journal details

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Demonstration of biological activity of brain gastrin-like peptidic material in the human: its relationship with the COOH-terminal octapeptide of cholecystokinin.

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