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PMID: 268651 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Cholecystokinin and its COOH-terminal octapeptide in the pig brain.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 7 ·1977-07-00 ·Pages 3035-7

Muller JE, Straus E, Yalow RS

Abstract

Two components--one resembling intact cholecystokinin in size and charge and immunologic specificity, and the other resembling the COOH-terminal octapeptide of cholecystokinin--have been found in extracts of the pig cerebral cortex. The relative concentrations of the two peptides in the extracts were dependent on the extractant, boiling 0.1 M HCl being more effective than boiling water for the extraction of intact cholecystokinin but less effective for the extraction of the octapeptide. The physiologic role of these peptides in the brain has yet to be elucidated.

MeSH Terms
Animals Cerebral Cortex/metabolism Cholecystokinin/metabolism Cross Reactions Gastrins/metabolism Molecular Weight Nerve Tissue Proteins/metabolism Oligopeptides/metabolism Radioimmunoassay Swine
Chemicals
Gastrins Nerve Tissue Proteins Oligopeptides Cholecystokinin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Muller J E
Straus E
Yalow R S
References (10)
10 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.74.7.3035
Published
1977-07-00
Pages
3035-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC431398
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.74.7.3035 PMC Full Text View journal details
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