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PMID: 26402601 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Mechanically Activated Ion Channels.

Neuron ·Vol. 87 ·No. 6 ·2015-09-23 ·Pages 1162-1179

Ranade SS, Syeda R, Patapoutian A

Abstract

Mechanotransduction, the conversion of physical forces into biochemical signals, is essential for various physiological processes such as the conscious sensations of touch and hearing, and the unconscious sensation of blood flow. Mechanically activated (MA) ion channels have been proposed as sensors of physical force, but the identity of these channels and an understanding of how mechanical force is transduced has remained elusive. A number of recent studies on previously known ion channels along with the identification of novel MA ion channels have greatly transformed our understanding of touch and hearing in both vertebrates and invertebrates. Here, we present an updated review of eukaryotic ion channel families that have been implicated in mechanotransduction processes and evaluate the qualifications of the candidate genes according to specified criteria. We then discuss the proposed gating models for MA ion channels and highlight recent structural studies of mechanosensitive potassium channels.

MeSH Terms
Animals Humans Ion Channel Gating/physiology Ion Channels/physiology Ion Transport/physiology Mechanotransduction, Cellular/physiology Sensation/physiology Touch/physiology
Chemicals
Ion Channels
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ranade Sanjeev S
Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Syeda Ruhma
Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Patapoutian Ardem
Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: ardem@scripps.edu.
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Article Info
Journal
Neuron
Abbr.
Neuron
ISSN
1097-4199
DOI
10.1016/j.neuron.2015.08.032
Email
ardem@scripps.edu
Published
2015-09-23
Pages
1162-1179
Language
English
Region
United States
NLM ID
8809320
PMCID
PMC4582600
Subset
IM
Grants
NIDCR NIH HHS · R01 DE022358 · United States
Howard Hughes Medical Institute · United States
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1016/j.neuron.2015.08.032 PMC Full Text View journal details
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