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PMID: 25488929 Published · ppublish English Journal Article

Achievements and challenges in structural bioinformatics and computational biophysics.

Bioinformatics (Oxford, England) ·Vol. 31 ·No. 1 ·2015-01-01 ·Pages 146-50

Samish I, Bourne PE, Najmanovich RJ

Abstract

The field of structural bioinformatics and computational biophysics has undergone a revolution in the last 10 years. Developments that are captured annually through the 3DSIG meeting, upon which this article reflects. An increase in the accessible data, computational resources and methodology has resulted in an increase in the size and resolution of studied systems and the complexity of the questions amenable to research. Concomitantly, the parameterization and efficiency of the methods have markedly improved along with their cross-validation with other computational and experimental results. The field exhibits an ever-increasing integration with biochemistry, biophysics and other disciplines. In this article, we discuss recent achievements along with current challenges within the field.

MeSH Terms
Achievement Biomedical Research/trends Biophysics/trends Computational Biology/trends Humans
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Samish Ilan
Department of Plant Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel, Ort Braude College, Karmiel, 2161002, Israel, Office of the Director, National Institutes of Health, Bethesda, MD 20814, USA and Department of Biochemistry, University of Sherbrooke, Sherbrooke, J1H 5N4, Canada Department of Plant Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel, Ort Braude College, Karmiel, 2161002, Israel, Office of the Director, National Institutes of Health, Bethesda, MD 20814, USA and Department of Biochemistry, University of Sherbrooke, Sherbrooke, J1H 5N4, Canada.
Bourne Philip E
Department of Plant Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel, Ort Braude College, Karmiel, 2161002, Israel, Office of the Director, National Institutes of Health, Bethesda, MD 20814, USA and Department of Biochemistry, University of Sherbrooke, Sherbrooke, J1H 5N4, Canada.
Najmanovich Rafael J
Department of Plant Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel, Ort Braude College, Karmiel, 2161002, Israel, Office of the Director, National Institutes of Health, Bethesda, MD 20814, USA and Department of Biochemistry, University of Sherbrooke, Sherbrooke, J1H 5N4, Canada.
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Article Info
Journal
Bioinformatics (Oxford, England)
Abbr.
Bioinformatics
ISSN
1367-4811
DOI
10.1093/bioinformatics/btu769
Published
2015-01-01
Epub
2014-00-08
Pages
146-50
Language
English
Region
England
NLM ID
9808944
PMCID
PMC4271151
Subset
IM
External Links
PubMed source DOI: 10.1093/bioinformatics/btu769 PMC Full Text View journal details
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