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PMID: 23203873 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures.

Nucleic acids research ·Vol. 41 ·No. Database issue ·2013-01-00 ·Pages D490-8

Sillitoe I, Cuff AL, Dessailly BH, Dawson NL, Furnham N, Lee D, Lees JG, Lewis TE, Studer RA, Rentzsch R, Yeats C, Thornton JM, Orengo CA

Abstract

CATH version 3.5 (Class, Architecture, Topology, Homology, available at http://www.cathdb.info/) contains 173 536 domains, 2626 homologous superfamilies and 1313 fold groups. When focusing on structural genomics (SG) structures, we observe that the number of new folds for CATH v3.5 is slightly less than for previous releases, and this observation suggests that we may now know the majority of folds that are easily accessible to structure determination. We have improved the accuracy of our functional family (FunFams) sub-classification method and the CATH sequence domain search facility has been extended to provide FunFam annotations for each domain. The CATH website has been redesigned. We have improved the display of functional data and of conserved sequence features associated with FunFams within each CATH superfamily.

MeSH Terms
Databases, Protein Genomics Internet Molecular Sequence Annotation Protein Folding Protein Structure, Tertiary Proteins/chemistry,classification,genetics Sequence Alignment Sequence Analysis, Protein Structural Homology, Protein
Chemicals
Proteins
Authors & Affiliations
13 authors, click to expand affiliations / ORCID
Sillitoe Ian
Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, UK.
Cuff Alison L
Dessailly Benoit H
Dawson Natalie L
Furnham Nicholas
Lee David
Lees Jonathan G
Lewis Tony E
Studer Romain A
Rentzsch Robert
Yeats Corin
Thornton Janet M
Orengo Christine A
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
1362-4962
DOI
10.1093/nar/gks1211
Published
2013-01-00
Epub
2012-00-29
Pages
D490-8
Language
English
Region
England
NLM ID
0411011
PMCID
PMC3531114
Subset
IM
Grants
Biotechnology and Biological Sciences Research Council · BB/F010451/1 · United Kingdom
NIAID NIH HHS · HHSN272201200026C · United States
Wellcome Trust · United Kingdom
Medical Research Council · United Kingdom
External Links
PubMed source DOI: 10.1093/nar/gks1211 PMC Full Text View journal details
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