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PMID: 2548184 Published · ppublish English Journal Article

The mouse homolog of the hst/k-FGF gene is adjacent to int-2 and is activated by proviral insertion in some virally induced mammary tumors.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 15 ·1989-08-00 ·Pages 5678-82

Peters G, Brookes S, Smith R, Placzek M, Dickson C

Abstract

The fibroblast growth factor-related protooncogenes, int-2 and hst/k-FGF, are within 17 kilobase pairs of one another on mouse chromosome 7 and are in the same transcriptional orientation. Approximately 70% of tumors induced in BR6 mice by mouse mammary tumor virus have proviral insertions adjacent to the int-2 gene. We find that the murine homolog of the hst/k-FGF gene can also be transcriptionally activated by the insertion of mouse mammary tumor virus DNA either upstream or downstream of the gene. In most tumors, only one of these adjacent genes is activated, but in some cases both genes are expressed. One of the hst-expressing tumors also has a virally activated int-3 gene. At least five distinct cellular genes (int-1, -2, -3, -4, and hst/k-FGF) can therefore contribute, either singly or in concert, to the development of histologically indistinguishable mammary tumors in mice infected by mouse mammary tumor virus.

MeSH Terms
Animals Base Sequence Chromosome Mapping DNA Transposable Elements DNA, Viral/genetics Fibroblast Growth Factors/genetics Gene Expression Regulation Genes Genetic Linkage Mammary Neoplasms, Experimental/genetics,microbiology Mammary Tumor Virus, Mouse/genetics Mice Molecular Sequence Data Proto-Oncogenes Restriction Mapping
Chemicals
DNA Transposable Elements DNA, Viral Fibroblast Growth Factors
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Peters G
Imperial Cancer Research Fund Laboratories, St. Bartholomews Hospital, London, United Kingdom.
Brookes S
Smith R
Placzek M
Dickson C
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31 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.15.5678
Published
1989-08-00
Pages
5678-82
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC297693
Subset
IM
Databases
GENBANK
M28516
External Links
PubMed source DOI: 10.1073/pnas.86.15.5678 PMC Full Text View journal details
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