A putative int domain for mouse mammary tumor virus on mouse chromosome 7 is a 5' extension of int-2.

Journal of virology ·Vol. 63 ·No. 3 ·1989-03-00 ·Pages 1448-50

Peters G, Brookes S, Placzek M, Schuermann M, Michalides R, Dickson C

Abstract

We extended the physical map of the mouse int-2 locus by demonstrating that the site of insertion for mouse mammary tumor virus DNA in plaque-type mammary tumors of GR mice is directly linked to int-2. An additional example of proviral integration is described in which a provirus in a presumed enhancer-insertion mode 15 kilobases upstream of the int-2 promoters is capable of activating expression of the gene at levels typical of other virally induced mammary tumors.

MeSH Terms

Animals Chromosome Mapping Mammary Tumor Virus, Mouse/genetics Mice/genetics Restriction Mapping

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Peters G

Imperial Cancer Research Fund Laboratories, St. Bartholomews Hospital, London, United Kingdom.

Brookes S

Placzek M

Schuermann M

Michalides R

Dickson C

References (13)

13 references, click to expand

Multiple RNAs expressed from the int-2 gene in mouse embryonal carcinoma cell lines encode a protein with homology to fibroblast growth factors.
EMBO J. 1988 Apr;7(4):1013-22 PMID: 2841106
Four classes of mRNA are expressed from the mouse int-2 gene, a member of the FGF gene family.
EMBO J. 1988 Jul;7(7):2035-41 PMID: 3416832
The activation of cellular oncogenes by proviral insertion in murine mammary cancer.
Cancer Treat Res. 1988;40:283-306 PMID: 2908657
Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15.
Nature. 1984 Jan 12-18;307(5947):131-6 PMID: 6318122
Mouse mammary tumor virus integration regions int-1 and int-2 map on different mouse chromosomes.
Mol Cell Biol. 1984 Feb;4(2):375-8 PMID: 6321961
Tumorigenesis by mouse mammary tumor virus: proviral activation of a cellular gene in the common integration region int-2.
Cell. 1984 Jun;37(2):529-36 PMID: 6327073
A rare common integration site of proviruses of the mouse mammary tumor virus in P-type mammary tumors of mouse strain GR.
Virology. 1987 Feb;156(2):229-37 PMID: 3027974
A common mouse mammary tumor virus integration site in chemically induced precancerous mammary hyperplasias.
Virology. 1986 Jan 30;148(2):360-8 PMID: 3002039
A new site of integration for mouse mammary tumor virus proviral DNA common to BALB/cf(C3H) mammary and kidney adenocarcinomas.
EMBO J. 1986 Jan;5(1):127-34 PMID: 3007110
Concerted activation of two potential proto-oncogenes in carcinomas induced by mouse mammary tumour virus.
Nature. 1986 Apr 17-23;320(6063):628-31 PMID: 3010125
A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17.
J Virol. 1987 Jan;61(1):218-20 PMID: 3023699
Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors.
J Virol. 1987 Jan;61(1):66-74 PMID: 3023708
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome.
Cell. 1982 Nov;31(1):99-109 PMID: 6297757

Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.63.3.1448-1450.1989

Published

1989-03-00

Pages

1448-50

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC247849

Subset

External Links

PubMed source DOI: 10.1128/JVI.63.3.1448-1450.1989 PMC Full Text View journal details

Analysis Services

A putative int domain for mouse mammary tumor virus on mouse chromosome 7 is a 5' extension of int-2.

Contact

WeChat Official Account