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PMID: 3023708 Published · ppublish English Journal Article

Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors.

Journal of virology ·Vol. 61 ·No. 1 ·1987-01-00 ·Pages 66-74

Gallahan D, Callahan R

Abstract

A population of Mus musculus subsp. musculus (Czech II), recently isolated from the wild, lack endogenous mouse mammary tumor virus (MMTV) proviral genomes. Some of these mice carry an infectious MMTV [designated MMTV (Czech II)] that is transmitted in the milk and is associated with mammary tumor development. This virus is distinct from laboratory strains of MMTV present in inbred mice. An MMTV (Czech II) genome was found within a 0.5-kilobase region of the cellular genome in five of 16 Czech II mammary tumors. MMTV insertion at this site activates expression of a 2.4-kilobase species of RNA from a previously silent cellular gene. This region of the cellular genome was designated int-3 since it is unrelated to the int-1 and int-2 loci. The int-3 locus does not appear to correspond to other proto-oncogenes but is well conserved among mammalian species.

MeSH Terms
Animals Cloning, Molecular DNA Restriction Enzymes DNA, Neoplasm/genetics,isolation & purification DNA, Viral/genetics,isolation & purification Mammary Neoplasms, Experimental/microbiology Mammary Tumor Virus, Mouse/genetics Mice Plasmids
Chemicals
DNA, Neoplasm DNA, Viral DNA Restriction Enzymes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gallahan D
Callahan R
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31 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.61.1.66-74.1987
Published
1987-01-00
Pages
66-74
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC255203
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.61.1.66-74.1987 PMC Full Text View journal details
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