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PMID: 2511424 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Homeosis and the interaction of zeste and white in Drosophila.

Molecular & general genetics : MGG ·Vol. 218 ·No. 3 ·1989-09-00 ·Pages 559-64

Wu CT, Jones RS, Lasko PF, Gelbart WM

Abstract

Transvection effects in Drosophila melanogaster suggest a form of gene modulation that is responsive to the proximity of homologous genes. These effects have been well characterized at bithorax and decapentaplegic, and in the interaction between the zeste and white genes. The mechanistic basis for transvection is not known. As part of a genetic analysis of transvection, a study is being made of a class of mutations defined as modifiers of the eye color resulting from the interaction of zeste and white. This report details the observations that several of these mutations also have homeotic effects.

MeSH Terms
Animals Drosophila melanogaster/genetics Eye Color Gene Rearrangement Genes, Lethal Genotype Suppression, Genetic
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Wu C T
Department of Biology, Yale University, New Haven, CT 06511-8112.
Jones R S
Lasko P F
Gelbart W M
References (29)
29 references, click to expand
  1. DNA-binding properties of the Drosophila melanogaster zeste gene product.
    Mol Cell Biol. 1988 Feb;8(2):615-23 PMID: 3127690
  2. In vivo binding pattern of a trans-regulator of homoeotic genes in Drosophila melanogaster.
    Nature. 1989 Feb 2;337(6206):468-71 PMID: 2563569
  3. Changes of zeste phenotype induced by autosomal mutations in Drosophila melanogaster.
    Hereditas. 1974;78(1):97-104 PMID: 4217331
  4. Cytogenetic fine structure and chromosomal localization of the white gene in Drosophila melanogaster.
    Nat New Biol. 1973 Sep 12;245(141):34-7 PMID: 4125726
  5. Molecular cloning, germ-line transformation, and transcriptional analysis of the zeste locus of Drosophila melanogaster.
    Proc Natl Acad Sci U S A. 1986 Feb;83(3):701-5 PMID: 3080747
  6. Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila.
    Proc Natl Acad Sci U S A. 1988 Nov;85(21):8136-40 PMID: 3141923
  7. Zeste encodes a sequence-specific transcription factor that activates the Ultrabithorax promoter in vitro.
    Cell. 1988 Jun 3;53(5):713-22 PMID: 3131017
  8. The Drosophila zeste gene and transvection.
    Trends Genet. 1989 Jun;5(6):189-94 PMID: 2505416
  9. Allelic pairing and gene regulation: A model for the zeste-white interaction in Drosophila melanogaster.
    Proc Natl Acad Sci U S A. 1979 Mar;76(3):1368-72 PMID: 16592632
  10. Genetic Analysis of the Hairy Locus in DROSOPHILA MELANOGASTER.
    Genetics. 1985 Nov;111(3):463-86 PMID: 17246301
  11. Interactions of zeste mutations with loci exhibiting transvection effects in Drosophila melanogaster.
    Genetics. 1982 Oct;102(2):179-89 PMID: 6818101
  12. Structure and sequence of the Drosophila zeste gene.
    EMBO J. 1987 Mar;6(3):791-9 PMID: 3582372
  13. Isolation and characterization of the zeste locus of Drosophila.
    EMBO J. 1985 Aug;4(8):2045-52 PMID: 16453631
  14. The product of the Drosophila zeste gene binds to specific DNA sequences in white and Ubx.
    EMBO J. 1987 May;6(5):1387-92 PMID: 3608982
  15. The interaction of two complex loci, zeste and bithorax in Drosophila melanogaster.
    Genetics. 1973 Oct;75(2):299-321 PMID: 4203579
  16. A minute mutant with suppressor effect on the eye-colour gene zeste in Drosophila melanogaster.
    Hereditas. 1976;82(1):57-62 PMID: 816760
  17. Establishment of compartments in the developing leg imaginal discs ofDrosophila melanogaster.
    Wilehm Roux Arch Dev Biol. 1976 Mar;180(1):9-30 PMID: 28304893
  18. Developmental expression of the Drosophila zeste gene and localization of zeste protein on polytene chromosomes.
    Genes Dev. 1988 Dec;2(12B):1839-50 PMID: 2853686
  19. Modification of the eye colour mutant zeste by suppressor, enhancer and minute genes in Drosophila melanogaster.
    Hereditas. 1976;82(1):111-9 PMID: 816757
  20. Lethal mutations flanking the 68C glue gene cluster on chromosome 3 of Drosophila melanogaster.
    Genetics. 1986 Apr;112(4):785-802 PMID: 3082712
  21. The Drosophila zeste protein binds cooperatively to sites in many gene regulatory regions: implications for transvection and gene regulation.
    EMBO J. 1988 Dec 1;7(12):3907-15 PMID: 3145199
  22. The ash-1, ash-2 and trithorax genes of Drosophila melanogaster are functionally related.
    Genetics. 1989 Mar;121(3):517-25 PMID: 2497049
  23. Dosage-Dependent Modifiers of Homoeotic Mutations in Drosophila melanogaster.
    Genetics. 1987 May;116(1):75-86 PMID: 17246380
  24. Genetic interactions of the suppressor 2 of zeste region genes.
    Dev Genet. 1989;10(3):249-60 PMID: 2500288
  25. Studies of the genetic organization of the vestigial microregion of Drosophila melanogaster.
    Genetics. 1988 Oct;120(2):495-502 PMID: 3143621
  26. Nucleotide sequence and structural analysis of the zeste locus of Drosophila melanogaster.
    Mol Gen Genet. 1988 Jan;211(1):121-8 PMID: 3125410
  27. Maternal expression of genes that regulate the bithorax complex of Drosophila melanogaster.
    Dev Biol. 1986 Dec;118(2):442-56 PMID: 3098596
  28. Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster : I. Zygotic loci on the second chromosome.
    Wilehm Roux Arch Dev Biol. 1984 Sep;193(5):267-282 PMID: 28305337
  29. Transvection: allelic cross talk.
    Cell. 1988 Jun 17;53(6):841-3 PMID: 2838174
Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00332424
Published
1989-09-00
Pages
559-64
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00332424
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