Genetic Analysis of the Hairy Locus in DROSOPHILA MELANOGASTER.

Genetics ·Vol. 111 ·No. 3 ·1985-11-00 ·Pages 463-86

Ingham PW, Pinchin SM, Howard KR, Ish-Horowicz D

Abstract

Mutations of the hairy locus in Drosophila may affect both adult chaeta differentiation and embryonic segmentation. In an effort to understand this phenotypic complexity, we have analyzed 30 mutant alleles of the locus. We find that the alleles fall into four groups according to their complementation properties, suggesting a structurally complex locus in which two distinct functions share a common coding region.

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Ingham P W

Developmental Genetics Laboratory, Imperial Cancer Research Fund, Mill Hill, London NW7 1AD, England.

Pinchin S M

Howard K R

Ish-Horowicz D

References (4)

4 references, click to expand

The molecular basis of P-M hybrid dysgenesis: the role of the P element, a P-strain-specific transposon family.
Cell. 1982 Jul;29(3):995-1004 PMID: 6295641
Cloning sequences from the hairy gene of Drosophila.
EMBO J. 1984 Mar;3(3):569-73 PMID: 6425055
Gene-dose titration analysis in the search of trans-regulatory genes in Drosophila.
EMBO J. 1982;1(3):307-10 PMID: 7188185
The biochemical genetics of rudimentary mutants of Drosophila melanogaster. I. Aspartate carbamoyltransferase levels in complementing and non-complementing strains.
Hereditas. 1973;73(1):11-6 PMID: 4218218

Article Info

Journal

Genetics

Abbr.

Genetics

ISSN

0016-6731

DOI

10.1093/genetics/111.3.463

Published

1985-11-00

Pages

463-86

Language

English

Region

United States

NLM ID

0374636

PMCID

PMC1202654

External Links

PubMed source DOI: 10.1093/genetics/111.3.463 PMC Full Text View journal details

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