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PMID: 25100531 Published · ppublish English Journal Article Review

Preparing the ground for tissue regeneration: from mechanism to therapy.

Nature medicine ·Vol. 20 ·No. 8 ·2014-08-00 ·Pages 857-69

Forbes SJ, Rosenthal N

Abstract

Chronic diseases confer tissue and organ damage that reduce quality of life and are largely refractory to therapy. Although stem cells hold promise for treating degenerative diseases by 'seeding' injured tissues, the regenerative capacity of stem cells is influenced by regulatory networks orchestrated by local immune responses to tissue damage, with macrophages being a central component of the injury response and coordinator of tissue repair. Recent research has turned to how cellular and signaling components of the local stromal microenvironment (the 'soil' to the stem cells' seed), such as local inflammatory reactions, contribute to successful tissue regeneration. This Review discusses the basic principles of tissue regeneration and the central role locally acting components may play in the process. Application of seed-and-soil concepts to regenerative medicine strengthens prospects for developing cell-based therapies or for promotion of endogenous repair.

MeSH Terms
Cell Differentiation Cell- and Tissue-Based Therapy Humans Inflammation Macrophages/cytology Mast Cells/cytology Neutrophils/cytology Regeneration/physiology Regenerative Medicine/methods Stem Cell Niche Stem Cell Transplantation Wound Healing
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Forbes Stuart J
MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.
Rosenthal Nadia
1] National Heart and Lung Institute, Imperial College London, London, UK. [2] Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia.
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Article Info
Journal
Nature medicine
Abbr.
Nat Med
ISSN
1546-170X
DOI
10.1038/nm.3653
Published
2014-08-00
Pages
857-69
Language
English
Region
United States
NLM ID
9502015
Subset
IM
Grants
Medical Research Council · G1000868 · United Kingdom
Medical Research Council · MR/K026666/1 · United Kingdom
British Heart Foundation · PG/10/19/28218 · United Kingdom
External Links
PubMed source DOI: 10.1038/nm.3653 View journal details
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