Home LiteratureArticle Details
PMID: 23307733 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure.

Science (New York, N.Y.) ·Vol. 339 ·No. 6116 ·2013-01-11 ·Pages 161-6

Swirski FK, Nahrendorf M

Abstract

Cardiovascular diseases claim more lives worldwide than any other. Etiologically, the dominant trajectory involves atherosclerosis, a chronic inflammatory process of lipid-rich lesion growth in the vascular wall that can cause life-threatening myocardial infarction (MI). Those who survive MI can develop congestive heart failure, a chronic condition of inadequate pump activity that is frequently fatal. Leukocytes (white blood cells) are important participants at the various stages of cardiovascular disease progression and complication. This Review will discuss leukocyte function in atherosclerosis, MI, and heart failure.

MeSH Terms
Adaptive Immunity Animals Atherosclerosis/complications,immunology,physiopathology Disease Progression Heart Failure/etiology,immunology,physiopathology Humans Leukocytes/immunology,physiology Macrophages/immunology,physiology Myocardial Infarction/etiology,immunology,physiopathology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Swirski Filip K
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA. fswirski@mgh.harvard.edu
Nahrendorf Matthias
References (56)
56 references, click to expand
  1. A tale of coronary artery disease and myocardial infarction.
    N Engl J Med. 2012 Jan 5;366(1):54-63 PMID: 22216842
  2. Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis.
    Circulation. 2010 Nov 2;122(18):1837-45 PMID: 20956207
  3. Acute myocardial infarction activates progenitor cells and increases Wnt signalling in the bone marrow.
    Eur Heart J. 2012 Aug;33(15):1911-9 PMID: 22173911
  4. An abundant tissue macrophage population in the adult murine heart with a distinct alternatively-activated macrophage profile.
    PLoS One. 2012;7(5):e36814 PMID: 22590615
  5. PET/MRI of inflammation in myocardial infarction.
    J Am Coll Cardiol. 2012 Jan 10;59(2):153-63 PMID: 22222080
  6. Current understanding of the role of B cell subsets and intimal and adventitial B cells in atherosclerosis.
    Curr Opin Lipidol. 2011 Oct;22(5):373-9 PMID: 21881498
  7. Macrophage autophagy plays a protective role in advanced atherosclerosis.
    Cell Metab. 2012 Apr 4;15(4):545-53 PMID: 22445600
  8. Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions.
    Circulation. 2012 Jan 17;125(2):364-74 PMID: 22144566
  9. Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice.
    Arterioscler Thromb Vasc Biol. 2009 Jan;29(1):19-26 PMID: 18948635
  10. Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe-/- mice during disease regression.
    J Clin Invest. 2011 May;121(5):2025-36 PMID: 21505265
  11. The role of the monocyte in atherogenesis: II. Migration of foam cells from atherosclerotic lesions.
    Am J Pathol. 1981 May;103(2):191-200 PMID: 7234962
  12. Regulatory role of dendritic cells in postinfarction healing and left ventricular remodeling.
    Circulation. 2012 Mar 13;125(10):1234-45 PMID: 22308302
  13. GM-CSF regulates intimal cell proliferation in nascent atherosclerotic lesions.
    J Exp Med. 2009 Sep 28;206(10):2141-9 PMID: 19752185
  14. Combined inhibition of CCL2, CX3CR1, and CCR5 abrogates Ly6C(hi) and Ly6C(lo) monocytosis and almost abolishes atherosclerosis in hypercholesterolemic mice.
    Circulation. 2008 Apr 1;117(13):1649-57 PMID: 18347211
  15. The immune response in atherosclerosis: a double-edged sword.
    Nat Rev Immunol. 2006 Jul;6(7):508-19 PMID: 16778830
  16. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E.
    Nat Med. 2003 Jan;9(1):61-7 PMID: 12483207
  17. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions.
    J Exp Med. 2007 Nov 26;204(12):3037-47 PMID: 18025128
  18. Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction.
    Blood. 2005 Jan 1;105(1):199-206 PMID: 15345590
  19. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses.
    Cell. 2012 Sep 28;151(1):138-52 PMID: 23021221
  20. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation.
    PLoS One. 2010 Jul 23;5(7):e11765 PMID: 20668705
  21. Leukocyte count and incidence of hospitalizations due to heart failure.
    Circ Heart Fail. 2009 May;2(3):217-22 PMID: 19808343
  22. Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis.
    J Clin Invest. 2012 Sep;122(9):3114-26 PMID: 22886300
  23. Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis.
    J Exp Med. 2012 Jan 16;209(1):123-37 PMID: 22213805
  24. The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques.
    Nat Immunol. 2012 Jan 08;13(2):136-43 PMID: 22231519
  25. Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata.
    J Clin Invest. 2007 Jan;117(1):195-205 PMID: 17200719
  26. Adaptive immunity and atherosclerosis.
    Clin Immunol. 2010 Jan;134(1):33-46 PMID: 19635683
  27. Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL.
    Arterioscler Thromb. 1994 Jan;14(1):32-40 PMID: 7506053
  28. Development of monocytes, macrophages, and dendritic cells.
    Science. 2010 Feb 5;327(5966):656-61 PMID: 20133564
  29. Atherosclerosis and leukocyte-endothelial adhesive interactions are increased following acute myocardial infarction in apolipoprotein E deficient mice.
    Atherosclerosis. 2010 Oct;212(2):414-7 PMID: 20619838
  30. Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure.
    Nature. 2012 May 10;485(7397):251-5 PMID: 22535248
  31. Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications.
    Circulation. 2007 Oct 16;116(16):1832-44 PMID: 17938300
  32. Protective role of natural IgM-producing B1a cells in atherosclerosis.
    Trends Cardiovasc Med. 2012 Feb;22(2):48-53 PMID: 22841841
  33. Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome.
    Cell Death Dis. 2011 Mar 31;2:e137 PMID: 21451572
  34. Flt3 signaling-dependent dendritic cells protect against atherosclerosis.
    Immunity. 2011 Nov 23;35(5):819-31 PMID: 22078798
  35. Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis.
    Circulation. 2008 Apr 1;117(13):1642-8 PMID: 18165355
  36. ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice.
    J Clin Invest. 2011 Oct;121(10):4138-49 PMID: 21968112
  37. Making a difference: monocyte heterogeneity in cardiovascular disease.
    Curr Atheroscler Rep. 2012 Oct;14(5):450-9 PMID: 22847772
  38. Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis.
    J Am Coll Cardiol. 2010 Apr 13;55(15):1629-38 PMID: 20378083
  39. The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.
    Am J Pathol. 1981 May;103(2):181-90 PMID: 7234961
  40. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
    Nature. 2010 Apr 29;464(7293):1357-61 PMID: 20428172
  41. Myocardial infarction accelerates atherosclerosis.
    Nature. 2012 Jul 19;487(7407):325-9 PMID: 22763456
  42. Macrophages in the pathogenesis of atherosclerosis.
    Cell. 2011 Apr 29;145(3):341-55 PMID: 21529710
  43. Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways.
    Cell Stem Cell. 2012 Aug 3;11(2):195-206 PMID: 22862945
  44. Impact of heterogeneity of human peripheral blood monocyte subsets on myocardial salvage in patients with primary acute myocardial infarction.
    J Am Coll Cardiol. 2009 Jul 7;54(2):130-8 PMID: 19573729
  45. LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression.
    J Clin Invest. 2010 Dec;120(12):4415-24 PMID: 21041949
  46. CCL2/Monocyte Chemoattractant Protein-1 regulates inflammatory responses critical to healing myocardial infarcts.
    Circ Res. 2005 Apr 29;96(8):881-9 PMID: 15774854
  47. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques.
    J Clin Invest. 2007 Jan;117(1):185-94 PMID: 17200718
  48. Therapeutic siRNA silencing in inflammatory monocytes in mice.
    Nat Biotechnol. 2011 Oct 09;29(11):1005-10 PMID: 21983520
  49. Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice.
    J Exp Med. 2009 Jan 16;206(1):233-48 PMID: 19139167
  50. Activation of CD4+ T lymphocytes improves wound healing and survival after experimental myocardial infarction in mice.
    Circulation. 2012 Apr 3;125(13):1652-63 PMID: 22388323
  51. Identification of splenic reservoir monocytes and their deployment to inflammatory sites.
    Science. 2009 Jul 31;325(5940):612-6 PMID: 19644120
  52. ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation.
    Science. 2010 Jun 25;328(5986):1689-93 PMID: 20488992
  53. Mast cells promote atherosclerosis by releasing proinflammatory cytokines.
    Nat Med. 2007 Jun;13(6):719-24 PMID: 17546038
  54. T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein.
    Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3893-7 PMID: 7732003
  55. Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves.
    J Exp Med. 2009 Mar 16;206(3):497-505 PMID: 19221394
  56. Adaptive immunity in atherosclerosis: mechanisms and future therapeutic targets.
    Nat Rev Cardiol. 2011 Jun;8(6):348-58 PMID: 21502963
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.1230719
Email
fswirski@mgh.harvard.edu
Published
2013-01-11
Pages
161-6
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC3891792
Subset
IM
Grants
NHLBI NIH HHS · R01 HL095612 · United States
NHLBI NIH HHS · R01HL095612 · United States
NHLBI NIH HHS · R01 HL096576 · United States
NHLBI NIH HHS · R01 HL095629 · United States
NHLBI NIH HHS · R01HL095629 · United States
NHLBI NIH HHS · R01HL096576 · United States
External Links
PubMed source DOI: 10.1126/science.1230719 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2