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PMID: 23619691 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Review

Macrophage biology in development, homeostasis and disease.

Nature ·Vol. 496 ·No. 7446 ·2013-04-25 ·Pages 445-55

Wynn TA, Chawla A, Pollard JW

Abstract

Macrophages, the most plastic cells of the haematopoietic system, are found in all tissues and show great functional diversity. They have roles in development, homeostasis, tissue repair and immunity. Although tissue macrophages are anatomically distinct from one another, and have different transcriptional profiles and functional capabilities, they are all required for the maintenance of homeostasis. However, these reparative and homeostatic functions can be subverted by chronic insults, resulting in a causal association of macrophages with disease states. In this Review, we discuss how macrophages regulate normal physiology and development, and provide several examples of their pathophysiological roles in disease. We define the 'hallmarks' of macrophages according to the states that they adopt during the performance of their various roles, taking into account new insights into the diversity of their lineages, identities and regulation. It is essential to understand this diversity because macrophages have emerged as important therapeutic targets in many human diseases.

MeSH Terms
Animals Cell Lineage Disease Fibrosis/metabolism,pathology Growth and Development Homeostasis Humans Macrophages/cytology,immunology,pathology,physiology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Wynn Thomas A
Immunopathogenesis Section, Program in Tissue Immunity and Repair and Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20877-8003, USA. twynn@niaid.nih.gov
Chawla Ajay
Pollard Jeffrey W
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature12034
Email
twynn@niaid.nih.gov
Published
2013-04-25
Pages
445-55
Language
English
Region
England
NLM ID
0410462
PMCID
PMC3725458
Subset
IM
Grants
NCI NIH HHS · P01 CA100324 · United States
NIAMS NIH HHS · DP1AR064158 · United States
NHLBI NIH HHS · HL076746 · United States
NIDDK NIH HHS · R01 DK081405 · United States
NHLBI NIH HHS · R01 HL076746 · United States
NIAMS NIH HHS · DP1 AR064158 · United States
NIH HHS · DP1 OD006415 · United States
NCI NIH HHS · P01CA100324 · United States
Intramural NIH HHS · United States
NIDDK NIH HHS · R01 DK094641 · United States
NCI NIH HHS · R01 CA131270 · United States
NCI NIH HHS · R01CA131270S · United States
Medical Research Council · G1002033 · United Kingdom
NICHD NIH HHS · U54HD058155 · United States
NIDDK NIH HHS · DK094641 · United States
External Links
PubMed source DOI: 10.1038/nature12034 PMC Full Text View journal details
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