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PMID: 21984069 Published · epublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Macrophage-mediated inflammation in metabolic disease.

Nature reviews. Immunology ·Vol. 11 ·No. 11 ·2011-10-10 ·Pages 738-49

Chawla A, Nguyen KD, Goh YP

Abstract

Metabolism and immunity are two fundamental systems of metazoans. The presence of immune cells, such as macrophages, in metabolic tissues suggests dynamic, ongoing crosstalk between these two regulatory systems. Here, we discuss how changes in the recruitment and activation of macrophages contribute to metabolic homeostasis. In particular, we focus our discussion on the pathogenic and protective functions of classically and alternatively activated macrophages, respectively, in experimental models of obesity and metabolic disease.

MeSH Terms
Animals Cytokines/immunology,metabolism Homeostasis/immunology Humans Inflammation Mediators/immunology,metabolism Insulin Resistance/immunology Macrophage Activation/immunology Macrophages/immunology Models, Immunological Obesity/immunology,metabolism
Chemicals
Cytokines Inflammation Mediators
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Chawla Ajay
Cardiovascular Research Institute, University of California San Francisco, California 94158-9001, USA. Ajay.Chawla@ucsf.edu
Nguyen Khoa D
Goh Y P Sharon
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri3071
Email
ajay.chawla@ucsf.edu
Published
2011-10-10
Epub
2011-00-10
Pages
738-49
Language
English
Region
England
NLM ID
101124169
PMCID
PMC3383854
Subset
IM
Grants
NHLBI NIH HHS · HL076746 · United States
NIDDK NIH HHS · R01 DK081405 · United States
NHLBI NIH HHS · R01 HL076746 · United States
NIAMS NIH HHS · DP1 AR064158 · United States
NIH HHS · DP1 OD006415 · United States
NIDDK NIH HHS · R01 DK094641 · United States
NIH HHS · DP1OD006415 · United States
NIDDK NIH HHS · DK076760 · United States
NIDDK NIH HHS · R01 DK076760 · United States
External Links
PubMed source DOI: 10.1038/nri3071 PMC Full Text View journal details
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