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PMID: 23307735 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis.

Science (New York, N.Y.) ·Vol. 339 ·No. 6116 ·2013-01-11 ·Pages 172-7

Odegaard JI, Chawla A

Abstract

Metabolism and immunity are inextricably linked both to each other and to organism-wide function, allowing mammals to adapt to changes in their internal and external environments. In the modern context of obesogenic diets and lifestyles, however, these adaptive responses can have deleterious consequences. In this Review, we discuss the pleiotropic actions of inflammation and insulin resistance in metabolic homeostasis and disease. An appreciation of the adaptive context in which these responses arose is useful for understanding their pathogenic actions in disease.

MeSH Terms
Adaptation, Physiological Animals Homeostasis Humans Immune System/physiology Inflammation/physiopathology Insulin Resistance Leukocytes/physiology Metabolic Diseases/physiopathology Metabolic Syndrome/physiopathology Metabolism Obesity/physiopathology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Odegaard Justin I
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158-9001, USA.
Chawla Ajay
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.1230721
Published
2013-01-11
Pages
172-7
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC3725457
Subset
IM
Grants
NIAMS NIH HHS · DP1AR064158 · United States
NHLBI NIH HHS · HL076746 · United States
NIDDK NIH HHS · R01 DK081405 · United States
NHLBI NIH HHS · R01 HL076746 · United States
NIAMS NIH HHS · DP1 AR064158 · United States
NIH HHS · DP1 OD006415 · United States
NIDDK NIH HHS · R01 DK094641 · United States
NIDDK NIH HHS · DK094641 · United States
External Links
PubMed source DOI: 10.1126/science.1230721 PMC Full Text View journal details
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