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PMID: 22035837 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Beginnings of a good apoptotic meal: the find-me and eat-me signaling pathways.

Immunity ·Vol. 35 ·No. 4 ·2011-10-28 ·Pages 445-55

Ravichandran KS

Abstract

Prompt and efficient clearance of apoptotic cells is necessary to prevent secondary necrosis of dying cells and to avoid immune responses to autoantigens. Recent studies have shed light on how apoptotic cells through soluble "find-me" signals advertise their presence to phagocytes at the earliest stages of cell death. Phagocytes sense the find-me signal gradient, and in turn the presence of dying cells, and migrate to their vicinity. The apoptotic cells also expose specific "eat-me" signals on their surface that are recognized by phagocytes through specific engulfment receptors. This review covers the recent progress in the areas of find-me and eat-me signals and how these relate to prompt and immunologically silent clearance of apoptotic cells.

MeSH Terms
Animals Apoptosis Humans Phagocytes Receptors, Cell Surface/metabolism Signal Transduction
Chemicals
Receptors, Cell Surface phosphatidylserine receptor
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ravichandran Kodi S
Department of Microbiology, Immunology, and Cancer Biology, Center for Cell Clearance, University of Virginia, Charlottesville, VA 22908, USA. ravi@virginia.edu
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Article Info
Journal
Immunity
Abbr.
Immunity
ISSN
1097-4180
DOI
10.1016/j.immuni.2011.09.004
Email
ravi@virginia.edu
Published
2011-10-28
Pages
445-55
Language
English
Region
United States
NLM ID
9432918
PMCID
PMC3241945
Subset
IM
Grants
NIGMS NIH HHS · R01 GM055761 · United States
NIGMS NIH HHS · R01 GM064709-08 · United States
NIGMS NIH HHS · GM064709 · United States
NIGMS NIH HHS · R01 GM055761-13 · United States
NIGMS NIH HHS · R01 GM064709 · United States
External Links
PubMed source DOI: 10.1016/j.immuni.2011.09.004 PMC Full Text View journal details
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