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PMID: 21123394 Published · epublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

Leukocytes in mammary development and cancer.

Cold Spring Harbor perspectives in biology ·Vol. 3 ·No. 3 ·2011-03-01

Coussens LM, Pollard JW

Abstract

Leukocytes, of both the innate and adaptive lineages, are normal cellular components of all tissues. These important cells not only are critical for regulating normal tissue homeostasis, but also are significant paracrine regulators of all physiologic and pathologic tissue repair processes. This article summarizes recent insights regarding the trophic roles of leukocytes at each stage of mammary gland development and during cancer development, with a focus on Murids and humans.

MeSH Terms
Animals Breast Neoplasms/immunology Collagen/metabolism Eosinophils/metabolism Female Humans Immunity, Humoral/immunology Lactation/physiology Leukocytes/immunology,physiology Macrophages/metabolism Mammary Glands, Human/cytology,growth & development,immunology Mast Cells/metabolism Mice Myeloid Cells/immunology Pregnancy T-Lymphocytes/immunology
Chemicals
Collagen
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Coussens Lisa M
Department of Pathology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 94143, USA.
Pollard Jeffrey W
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Article Info
Journal
Cold Spring Harbor perspectives in biology
Abbr.
Cold Spring Harb Perspect Biol
ISSN
1943-0264
DOI
10.1101/cshperspect.a003285
Published
2011-03-01
Epub
2011-00-01
Language
English
Region
United States
NLM ID
101513680
PMCID
PMC3039933
Subset
IM
Corrections
CommentIn
PMID: 22550234
External Links
PubMed source DOI: 10.1101/cshperspect.a003285 PMC Full Text View journal details
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