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PMID: 1312220 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease.

Molecular and cellular biology ·Vol. 12 ·No. 3 ·1992-03-00 ·Pages 954-61

Guy CT, Cardiff RD, Muller WJ

Abstract

The effect of mammary gland-specific expression of the polyomavirus middle T antigen was examined by establishing lines of transgenic mice that carry the middle T oncogene under the transcriptional control of the mouse mammary tumor virus promoter/enhancer. By contrast to most transgenic strains carrying activated oncogenes, expression of polyomavirus middle T antigen resulted in the widespread transformation of the mammary epithelium and the rapid production of multifocal mammary adenocarcinomas. Interestingly, the majority of the tumor-bearing transgenic mice developed secondary metastatic tumors in the lung. Taken together, these results suggest that middle T antigen acts as a potent oncogene in the mammary epithelium and that cells that express it possess an enhanced metastatic potential.

MeSH Terms
Animals Antigens, Polyomavirus Transforming/genetics Cloning, Molecular Epithelium/metabolism Female Male Mammary Neoplasms, Experimental/genetics,immunology,pathology,secondary Mammary Tumor Virus, Mouse/genetics Mice Mice, Transgenic Models, Genetic Oncogenes Organ Specificity/genetics
Chemicals
Antigens, Polyomavirus Transforming
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Guy C T
Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada.
Cardiff R D
Muller W J
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.12.3.954-961.1992
Published
1992-03-00
Pages
954-61
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC369527
Subset
IM
Grants
NCI NIH HHS · R01-CAS4285 · United States
External Links
PubMed source DOI: 10.1128/mcb.12.3.954-961.1992 PMC Full Text View journal details
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