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PMID: 2476217 Published · ppublish English Journal Article Review

DNA methylation and cell memory.

Cell biophysics ·Vol. 15 ·No. 1-2 ·1989-00-00 ·Pages 1-13

Riggs AD

Abstract

In this paper we address the question: How do replicating mammalian cells remember with high fidelity their proper state of differentiation? Several possible mechanisms for cell memory are discussed, and it is concluded that only mechanisms involving DNA methylation are supported by strong experimental evidence. This evidence is reviewed. The establishment and modulation of methylation patterns are discussed and a hemimethylation model for stem cells is presented. The overall conclusion is that, although little is yet known about the details, there should be little doubt about the existence of a methylation system functioning at least to aid cell memory.

MeSH Terms
Animals Cell Differentiation DNA/metabolism,physiology DNA Replication Gene Expression Regulation Methylation Mice Stem Cells/metabolism
Chemicals
DNA
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Riggs A D
Biology Division, Beckman Research Institute of the City of Hope, City of Hope Medical Center, Duarte, CA 91010.
References (36)
36 references, click to expand
  1. The role of stable complexes that repress and activate eucaryotic genes.
    Cell. 1984 Jun;37(2):359-65 PMID: 6722879
  2. DNA replication in vitro erases a Xenopus 5S RNA gene transcription complex.
    Cell. 1986 Oct 24;47(2):217-27 PMID: 3021334
  3. Genomic sequencing reveals a positive correlation between the kinetics of strand-specific DNA demethylation of the overlapping estradiol/glucocorticoid-receptor binding sites and the rate of avian vitellogenin mRNA synthesis.
    Proc Natl Acad Sci U S A. 1986 Oct;83(19):7167-71 PMID: 3463957
  4. Substrate and sequence specificity of a eukaryotic DNA methylase.
    Nature. 1982 Feb 18;295(5850):620-2 PMID: 7057921
  5. Use of restriction enzymes to study eukaryotic DNA methylation: II. The symmetry of methylated sites supports semi-conservative copying of the methylation pattern.
    J Mol Biol. 1978 Jan 5;118(1):49-60 PMID: 625057
  6. Caenorhabditis elegans DNA does not contain 5-methylcytosine at any time during development or aging.
    Nucleic Acids Res. 1986 Aug 26;14(16):6711-9 PMID: 3748820
  7. DNA modification mechanisms and gene activity during development.
    Science. 1975 Jan 24;187(4173):226-32 PMID: 1111098
  8. Genomic imprinting determines methylation of parental alleles in transgenic mice.
    Nature. 1987 Jul 16-22;328(6127):248-51 PMID: 3600805
  9. Genomic sequencing.
    Proc Natl Acad Sci U S A. 1984 Apr;81(7):1991-5 PMID: 6326095
  10. Muscle-specific activation of a methylated chimeric actin gene.
    Cell. 1986 Aug 1;46(3):409-16 PMID: 3731275
  11. Methylation and the X chromosome.
    Bioessays. 1986 May;4(5):204-8 PMID: 3790119
  12. DNA methylation affects the formation of active chromatin.
    Cell. 1986 Feb 28;44(4):535-43 PMID: 3456276
  13. The inheritance of epigenetic defects.
    Science. 1987 Oct 9;238(4824):163-70 PMID: 3310230
  14. Cellular and viral DNA hypomethylation associated with induction of Epstein-Barr virus lytic cycle.
    Proc Natl Acad Sci U S A. 1985 Dec;82(23):8090-4 PMID: 2999791
  15. Determination of trace amounts of 5-methylcytosine in DNA by reverse-phase high-performance liquid chromatography.
    Anal Biochem. 1987 Jul;164(1):164-9 PMID: 2960248
  16. Differences in the DNA of the inactive X chromosomes of fetal and extraembryonic tissues of mice.
    Cell. 1983 May;33(1):37-42 PMID: 6678611
  17. Methylation patterns of repetitive DNA sequences in germ cells of Mus musculus.
    Nucleic Acids Res. 1984 Mar 26;12(6):2823-36 PMID: 6709503
  18. Simultaneous induction of epigenetic variants.
    Somat Cell Mol Genet. 1986 Nov;12(6):567-73 PMID: 2431487
  19. The lysis-lysogeny decision of phage lambda: explicit programming and responsiveness.
    Annu Rev Genet. 1980;14:399-445 PMID: 6452089
  20. Genomic imprinting. Memories of mother and father.
    Nature. 1987 Jul 16-22;328(6127):203-4 PMID: 3600803
  21. Methylation of DNA in mouse early embryos, teratocarcinoma cells and adult tissues of mouse and rabbit.
    Nucleic Acids Res. 1979 Dec 20;7(8):2369-85 PMID: 523320
  22. X inactivation, differentiation, and DNA methylation.
    Cytogenet Cell Genet. 1975;14(1):9-25 PMID: 1093816
  23. Parental legacy determines methylation and expression of an autosomal transgene: a molecular mechanism for parental imprinting.
    Cell. 1987 Aug 28;50(5):719-27 PMID: 3040259
  24. Transfection of a DNA locus that mediates the conversion of 10T1/2 fibroblasts to myoblasts.
    Cell. 1986 Dec 5;47(5):649-56 PMID: 2430720
  25. Degree of methylation of transgenes is dependent on gamete of origin.
    Nature. 1987 Jul 16-22;328(6127):251-4 PMID: 3600806
  26. Estimation of the amount of 5-methylcytosine in Drosophila melanogaster DNA by amplified ELISA and photoacoustic spectroscopy.
    EMBO J. 1984 Feb;3(2):263-6 PMID: 6232132
  27. Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
    Cell. 1979 Aug;17(4):771-9 PMID: 90553
  28. DNA methylation and gene function.
    Science. 1980 Nov 7;210(4470):604-10 PMID: 6254144
  29. Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development.
    Development. 1987 Mar;99(3):371-82 PMID: 3653008
  30. A nuclease-hypersensitive region forms de novo after chromosome replication.
    Mol Cell Biol. 1987 Oct;7(10):3822-5 PMID: 2824998
  31. Successful rescue of microsurgically produced homozygous uniparental mouse embryos via production of aggregation chimeras.
    Proc Natl Acad Sci U S A. 1986 Sep;83(17):6509-13 PMID: 3462710
  32. Differential activity of maternally and paternally derived chromosome regions in mice.
    Nature. 1985 Jun 6-12;315(6019):496-8 PMID: 4000278
  33. Replacement of 5-methylcytosine by cytosine: a possible mechanism for transient DNA demethylation during differentiation.
    Proc Natl Acad Sci U S A. 1986 May;83(9):2827-31 PMID: 3458243
  34. 5-methylcytosine, gene regulation, and cancer.
    Adv Cancer Res. 1983;40:1-30 PMID: 6197868
  35. Determinator-inhibitor pairs as a mechanism for threshold setting in development: a possible function for pseudogenes.
    Proc Natl Acad Sci U S A. 1986 Feb;83(3):679-83 PMID: 2418440
  36. Conservative segregation of parental histones during replication in the presence of cycloheximide.
    Proc Natl Acad Sci U S A. 1979 Jan;76(1):328-32 PMID: 284348
Article Info
Journal
Cell biophysics
Abbr.
Cell Biophys
ISSN
0163-4992
DOI
10.1007/BF02991574
Published
1989-00-00
Pages
1-13
Language
English
Region
United States
NLM ID
8002185
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02991574
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