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PMID: 2471070 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Conserved pattern of antisense overlapping transcription in the homologous human ERCC-1 and yeast RAD10 DNA repair gene regions.

Molecular and cellular biology ·Vol. 9 ·No. 4 ·1989-04-00 ·Pages 1794-8

van Duin M, van Den Tol J, Hoeijmakers JH, Bootsma D, Rupp IP, Reynolds P, Prakash L, Prakash S

Abstract

We report that the genes for the homologous Saccharomyces cerevisiae RAD10 and human ERCC-1 DNA excision repair proteins harbor overlapping antisense transcription units in their 3' regions. Since naturally occurring antisense transcription is rare in S. cerevisiae and humans (this is the first example in human cells), our findings indicate that antisense transcription in the ERCC-1-RAD10 gene regions represents an evolutionarily conserved feature.

MeSH Terms
Base Sequence Biological Evolution DNA/genetics DNA Repair DNA, Fungal/genetics Genes Genes, Fungal Genes, Overlapping Humans Molecular Sequence Data RNA/genetics RNA, Antisense Restriction Mapping Saccharomyces cerevisiae/genetics Transcription, Genetic
Chemicals
DNA, Fungal RNA, Antisense RNA DNA
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
van Duin M
Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands.
van Den Tol J
Hoeijmakers J H
Bootsma D
Rupp I P
Reynolds P
Prakash L
Prakash S
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.9.4.1794-1798.1989
Published
1989-04-00
Pages
1794-8
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC362600
Subset
IM
Databases
GENBANK
M26163
External Links
PubMed source DOI: 10.1128/mcb.9.4.1794-1798.1989 PMC Full Text View journal details
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