Home LiteratureArticle Details
PMID: 2470025 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Expression of a mouse replacement histone H3.3 gene with a highly conserved 3' noncoding region during SV40- and polyoma-induced Go to S-phase transition.

Nucleic acids research ·Vol. 17 ·No. 7 ·1989-04-11 ·Pages 2449-61

Hraba-Renevey S, Kress M

Abstract

We have isolated and sequenced a mouse replacement variant histone H3.3 cDNA. It corresponds to the most abundant mRNA expressed from a unique gene by the use of one out of three polyadenylation sites. The 3' non coding region of H3.3 is very long (approximately 1100 nt) and highly conserved throughout evolution since it is about 95% homologous to the 3' non coding region of the chicken H3.3B gene. We studied the expression of the H3.3 gene during SV40- and polyoma-induced mitotic host reaction in confluent, Go-arrested primary mouse kidney cell cultures. H3.3 replacement variant mRNA steady state levels increased during the Go to S-phase transition, apparently as the result of two mechanisms: one related to cell growth, whereas the other was linked to cellular DNA synthesis. The latter mechanism was however far less pronounced than with replication histone variant mRNAs. The biological implications of these results are discussed.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Cells, Cultured DNA/genetics Genetic Variation Histones/genetics,isolation & purification Interphase Kidney Mice Molecular Sequence Data Multigene Family Poly A/metabolism Polyomavirus/genetics RNA/isolation & purification RNA, Messenger/biosynthesis Simian virus 40/genetics
Chemicals
Histones RNA, Messenger Poly A RNA DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hraba-Renevey S
Department of Molecular Biology, University of Geneva, Switzerland.
Kress M
References (54)
54 references, click to expand
  1. Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing.
    Gene. 1984 Jun;28(3):351-9 PMID: 6235151
  2. A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.
    Science. 1987 Nov 6;238(4828):797-9 PMID: 3672127
  3. Transcription termination and 3' processing: the end is in site!
    Cell. 1985 Jun;41(2):349-59 PMID: 2580642
  4. Expression of enhanced levels of small RNA polymerase III transcripts encoded by the B2 repeats in simian virus 40-transformed mouse cells.
    Nature. 1985 Apr 11-17;314(6011):553-6 PMID: 2581137
  5. Structure of a human histone cDNA: evidence that basally expressed histone genes have intervening sequences and encode polyadenylylated mRNAs.
    Proc Natl Acad Sci U S A. 1985 May;82(9):2834-8 PMID: 2859593
  6. Inverted duplication of histone genes in chicken and disposition of regulatory sequences.
    Nucleic Acids Res. 1985 Feb 25;13(4):1369-87 PMID: 4000938
  7. The class I major histocompatibility antigen gene activated in a line of SV40-transformed mouse cells is H-2Dd, not Qa/Tla.
    Nature. 1985 Jul 11-17;316(6024):162-3 PMID: 2989712
  8. Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts.
    EMBO J. 1985 Jun;4(6):1435-40 PMID: 3875482
  9. Replacement variant histone genes contain intervening sequences.
    Mol Cell Biol. 1985 Jun;5(6):1307-17 PMID: 2863747
  10. hv1 is an evolutionarily conserved H2A variant that is preferentially associated with active genes.
    J Biol Chem. 1986 Feb 5;261(4):1941-8 PMID: 3944120
  11. Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells.
    EMBO J. 1985 Dec 1;4(12):3145-51 PMID: 3841511
  12. Cell-cycle regulation of histone gene expression.
    Cell. 1986 May 23;45(4):471-2 PMID: 3708685
  13. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.
    Proc Natl Acad Sci U S A. 1972 Jun;69(6):1408-12 PMID: 4504350
  14. "Early" virus-specific RNA may contain information necessary for chromosome replication and mitosis induced by Simian Virus 40.
    Proc Natl Acad Sci U S A. 1973 Jun;70(6):1654-8 PMID: 4352646
  15. Synthesis of histone messenger RNA of HeLa cells during the cell cycle.
    Cell. 1977 Sep;12(1):167-74 PMID: 902312
  16. Sequence and properties of the message encoding Tetrahymena hv1, a highly evolutionarily conserved histone H2A variant that is associated with active genes.
    Nucleic Acids Res. 1988 Jan 11;16(1):179-98 PMID: 3340523
  17. Sequence of cDNAs for mammalian H2A.Z, an evolutionarily diverged but highly conserved basal histone H2A isoprotein species.
    Nucleic Acids Res. 1988 Feb 11;16(3):1113-24 PMID: 3344202
  18. Complexity of the early genetic response to growth factors in mouse fibroblasts.
    Mol Cell Biol. 1988 May;8(5):2140-8 PMID: 2898731
  19. Drosophila has a single copy of the gene encoding a highly conserved histone H2A variant of the H2A.F/Z type.
    Nucleic Acids Res. 1988 Aug 11;16(15):7487-97 PMID: 3137528
  20. Early increase in histone H1(0) mRNA during differentiation of F9 cells to parietal endoderm.
    EMBO J. 1988 Oct;7(10):3003-8 PMID: 2846273
  21. Multiple regulatory steps control histone mRNA concentrations.
    Trends Biochem Sci. 1988 Feb;13(2):49-52 PMID: 3070846
  22. Multilevel regulation of replication-dependent histone genes.
    Trends Genet. 1988 Jul;4(7):187-91 PMID: 3070866
  23. A beginning to the biochemistry of polyadenylation.
    Trends Genet. 1988 Sep;4(9):243-5 PMID: 2853468
  24. One single burst of SV40 gene expression induces cell proliferation in transforming infection of mouse cells.
    Oncogene. 1988 Aug;3(2):195-200 PMID: 2842716
  25. DNA sequencing with chain-terminating inhibitors.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 PMID: 271968
  26. Regulation of histone gene expression in HeLa S3 cells.
    Cold Spring Harb Symp Quant Biol. 1978;42 Pt 2:1107-20 PMID: 277306
  27. Viral 'tumor antigens': A novel type of mammalian regulator protein.
    Biochim Biophys Acta. 1978 Nov 17;516(3):301-88 PMID: 215209
  28. Simian virus 40 and polyoma virus stimulate overall cellular RNA and protein synthesis.
    Proc Natl Acad Sci U S A. 1980 Mar;77(3):1476-80 PMID: 6154935
  29. Two-dimensional gel analysis of histones in acid extracts of nuclei, cells, and tissues.
    Eur J Biochem. 1980 Aug;109(1):17-23 PMID: 7408874
  30. Histone variants specific to the transcriptionally active, amitotically dividing macronucleus of the unicellular eucaryote, Tetrahymena thermophila.
    Cell. 1980 Jul;20(3):609-17 PMID: 7418000
  31. Isolation of two clusters of mouse histone genes.
    Proc Natl Acad Sci U S A. 1981 Jul;78(7):4078-82 PMID: 6457299
  32. Separation of basal histone synthesis from S-phase histone synthesis in dividing cells.
    Cell. 1981 Dec;27(2 Pt 1):321-30 PMID: 7199388
  33. Pattern recognition in nucleic acid sequences. I. A general method for finding local homologies and symmetries.
    Nucleic Acids Res. 1982 Jan 11;10(1):247-63 PMID: 6801626
  34. A chicken histone H3 gene contains intervening sequences.
    Nature. 1982 Jun 3;297(5865):434-6 PMID: 7078654
  35. SV40 large tumor antigen can regulate some cellular transcripts in a positive fashion.
    Cell. 1982 Sep;30(2):481-90 PMID: 6291771
  36. Patterns of histone variant synthesis can distinguish G0 from G1 cells.
    Cell. 1982 Dec;31(2 Pt 1):367-74 PMID: 7159927
  37. Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.
    Proc Natl Acad Sci U S A. 1983 Jul;80(13):3963-5 PMID: 6575390
  38. Molecular cloning of gene sequences regulated by platelet-derived growth factor.
    Cell. 1983 Jul;33(3):939-47 PMID: 6872001
  39. Growth-related changes in specific mRNAs of cultured mouse cells.
    Proc Natl Acad Sci U S A. 1983 Jul;80(14):4271-5 PMID: 6576337
  40. Activation of mouse genes in transformed cells.
    Cell. 1983 Sep;34(2):557-67 PMID: 6311432
  41. Sequential stimulation of cellular RNA synthesis in polyoma-infected mouse kidney cell cultures.
    Nucleic Acids Res. 1983 Oct 11;11(19):6611-29 PMID: 6314250
  42. Structure of a cluster of mouse histone genes.
    Nucleic Acids Res. 1983 Oct 11;11(19):6679-97 PMID: 6314253
  43. The primary structure and expression of four cloned human histone genes.
    Nucleic Acids Res. 1983 Nov 11;11(21):7409-25 PMID: 6647026
  44. Transcripts regulated during normal embryonic development and oncogenic transformation share a repetitive element.
    Cell. 1983 Dec;35(3 Pt 2):865-71 PMID: 6652687
  45. A simple and very efficient method for generating cDNA libraries.
    Gene. 1983 Nov;25(2-3):263-9 PMID: 6198242
  46. Cloning of sequences expressed specifically in tumors of rat.
    Proc Natl Acad Sci U S A. 1983 Dec;80(24):7524-7 PMID: 6200876
  47. UV crosslinking of RNA to nylon membrane enhances hybridization signals.
    Mol Biol Rep. 1986;11(2):107-15 PMID: 2426570
  48. Isolation of cellular genes differentially expressed in mouse NIH 3T3 cells and a simian virus 40-transformed derivative: growth-specific expression of VL30 genes.
    Mol Cell Biol. 1985 Oct;5(10):2590-8 PMID: 3016508
  49. On the functional roles of simian virus 40 large and small T-antigen in the induction of a mitotic host response.
    Nucleic Acids Res. 1986 Dec 9;14(23):9339-51 PMID: 2432477
  50. Codon usage in histone gene families of higher eukaryotes reflects functional rather than phylogenetic relationships.
    J Mol Evol. 1986;23(3):224-41 PMID: 3100813
  51. Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc.
    Proc Natl Acad Sci U S A. 1987 Mar;84(5):1182-6 PMID: 3469660
  52. Unusual structure, evolutionary conservation of non-coding sequences and numerous pseudogenes characterize the human H3.3 histone multigene family.
    Nucleic Acids Res. 1987 Apr 10;15(7):2871-89 PMID: 3031613
  53. Chicken histone H3.3B cDNA sequence confirms unusual 3' UTR structure.
    Nucleic Acids Res. 1987 Aug 11;15(15):6294 PMID: 3627987
  54. Small and middle T antigens contribute to lytic and abortive polyomavirus infection.
    J Virol. 1985 Feb;53(2):579-86 PMID: 2578576
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/17.7.2449
Published
1989-04-11
Pages
2449-61
Language
English
Region
England
NLM ID
0411011
PMCID
PMC317635
Subset
IM
Databases
GENBANK
X13605
External Links
PubMed source DOI: 10.1093/nar/17.7.2449 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2