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PMID: 2846273 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Early increase in histone H1(0) mRNA during differentiation of F9 cells to parietal endoderm.

The EMBO journal ·Vol. 7 ·No. 10 ·1988-10-00 ·Pages 3003-8

Alonso A, Breuer B, Bouterfa H, Doenecke D

Abstract

We have isolated and characterized cDNA clones coding for the H1 histone subtype H1(0) in mouse teratocarcinoma cells. The mRNA is 2100 nt long and contains a coding sequence which is highly related to that of the human H1(0) gene. Using this cDNA as a probe, we have shown that, in comparison to undifferentiated F9 cells, differentiated F9 teratocarcinoma cells contain large amounts of H1(0) mRNA. This increase takes place very early during differentiation and does not correlate with changes in the rate of cell division. This indicates that the accumulation of H1(0) mRNA is not the result of reduced proliferation. Most likely on the contrary, the increase in the amount of H1(0) and the resulting effects on the formation of high order chromatin structures are parts of the differentiation program induced in F9 cells.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Bucladesine/pharmacology Cell Cycle Cell Differentiation Cloning, Molecular Endoderm/cytology,physiology Gene Expression Regulation/drug effects Histones/genetics Mice Molecular Sequence Data RNA, Messenger/genetics Teratoma/genetics,pathology Tretinoin/pharmacology
Chemicals
Histones RNA, Messenger Tretinoin Bucladesine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Alonso A
German Cancer Research Center, Institute of Experimental Pathology, Heidelberg.
Breuer B
Bouterfa H
Doenecke D
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29 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1988-10-00
Pages
3003-8
Language
English
Region
England
NLM ID
8208664
PMCID
PMC454684
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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