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PMID: 4000938 Published · ppublish English Journal Article

Inverted duplication of histone genes in chicken and disposition of regulatory sequences.

Nucleic acids research ·Vol. 13 ·No. 4 ·1985-02-25 ·Pages 1369-87

Wang SW, Robins AJ, d'Andrea R, Wells JR

Abstract

Sequence analysis of an 8.4 kb fragment containing five chicken histone genes shows that an H4-H2A gene pair is duplicated and inverted around a central H3 gene. A left and right region, each of 2.1 kb are 97% homologous and the boundaries of homology coincide with ten base pair repeats. These boundary regions also contain highly conserved gene promoter elements, suggesting that interaction of transcriptional machinery with histone genes may be connected with recombination in promoter regions, resulting in the inverted duplication structure seen in this cluster.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Chickens/genetics Genes Genes, Regulator Genetic Linkage Histones/genetics Promoter Regions, Genetic Transcription, Genetic
Chemicals
Histones
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Wang S W
Robins A J
d'Andrea R
Wells J R
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23 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/13.4.1369
Published
1985-02-25
Pages
1369-87
Language
English
Region
England
NLM ID
0411011
PMCID
PMC341078
Subset
IM
Databases
GENBANK
X02218
External Links
PubMed source DOI: 10.1093/nar/13.4.1369 PMC Full Text View journal details
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