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PMID: 23550210 Published · epublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal.

Science signaling ·Vol. 6 ·No. 269 ·2013-04-02 ·Pages pl1

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, Cerami E, Sander C, Schultz N

Abstract

The cBioPortal for Cancer Genomics (http://cbioportal.org) provides a Web resource for exploring, visualizing, and analyzing multidimensional cancer genomics data. The portal reduces molecular profiling data from cancer tissues and cell lines into readily understandable genetic, epigenetic, gene expression, and proteomic events. The query interface combined with customized data storage enables researchers to interactively explore genetic alterations across samples, genes, and pathways and, when available in the underlying data, to link these to clinical outcomes. The portal provides graphical summaries of gene-level data from multiple platforms, network visualization and analysis, survival analysis, patient-centric queries, and software programmatic access. The intuitive Web interface of the portal makes complex cancer genomics profiles accessible to researchers and clinicians without requiring bioinformatics expertise, thus facilitating biological discoveries. Here, we provide a practical guide to the analysis and visualization features of the cBioPortal for Cancer Genomics.

MeSH Terms
Gene Expression Profiling Gene Regulatory Networks Genetic Predisposition to Disease/genetics Genomics Humans Information Storage and Retrieval/methods Internet Neoplasms/genetics,pathology Reproducibility of Results Software
Authors & Affiliations
13 authors, click to expand affiliations / ORCID
Gao Jianjiong
Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Aksoy Bülent Arman
Dogrusoz Ugur
Dresdner Gideon
Gross Benjamin
Sumer S Onur
Sun Yichao
Jacobsen Anders
Sinha Rileen
Larsson Erik
Cerami Ethan
Sander Chris
Schultz Nikolaus
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Article Info
Journal
Science signaling
Abbr.
Sci Signal
ISSN
1937-9145
DOI
10.1126/scisignal.2004088
Published
2013-04-02
Epub
2013-00-02
Pages
pl1
Language
English
Region
United States
NLM ID
101465400
PMCID
PMC4160307
Subset
IM
Grants
NCI NIH HHS · U24CA143840 · United States
NCRR NIH HHS · P41 RR031228 · United States
NCI NIH HHS · R01 CA132744 · United States
NIGMS NIH HHS · P41 GM103504 · United States
NCI NIH HHS · R21 CA135870 · United States
NCI NIH HHS · U24 CA143840 · United States
NIGMS NIH HHS · GM103504 · United States
NCI NIH HHS · R21CA135870 · United States
External Links
PubMed source DOI: 10.1126/scisignal.2004088 PMC Full Text View journal details
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