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PMID: 20393554 Published · ppublish English Journal Article

International network of cancer genome projects.

Nature ·Vol. 464 ·No. 7291 ·2010-04-15 ·Pages 993-8

International Cancer Genome Consortium, Hudson TJ, Anderson W, Artez A, Barker AD, Bell C, Bernabé RR, Bhan MK, Calvo F, Eerola I, Gerhard DS, Guttmacher A, Guyer M, Hemsley FM, Jennings JL, Kerr D, Klatt P, Kolar P, Kusada J, Lane DP, Laplace F, Youyong L, Nettekoven G, Ozenberger B, Peterson J, Rao TS, Remacle J, Schafer AJ, Shibata T, Stratton MR, Vockley JG, Watanabe K, Yang H, Yuen MM, Knoppers BM, Bobrow M, Cambon-Thomsen A, Dressler LG, Dyke SO, Joly Y, Kato K, Kennedy KL, Nicolás P, Parker MJ, Rial-Sebbag E, Romeo-Casabona CM, Shaw KM, Wallace S, Wiesner GL, Zeps N, Lichter P, Biankin AV, Chabannon C, Chin L, Clément B, de Alava E, Degos F, Ferguson ML, Geary P, Hayes DN, Hudson TJ, Johns AL, Kasprzyk A, Nakagawa H, Penny R, Piris MA, Sarin R, Scarpa A, Shibata T, van de Vijver M, Futreal PA, Aburatani H, Bayés M, Botwell DD, Campbell PJ, Estivill X, Gerhard DS, Grimmond SM, Gut I, Hirst M, López-Otín C, Majumder P, Marra M, McPherson JD, Nakagawa H, Ning Z, Puente XS, Ruan Y, Shibata T, Stratton MR, Stunnenberg HG, Swerdlow H, Velculescu VE, Wilson RK, Xue HH, Yang L, Spellman PT, Bader GD, Boutros PC, Campbell PJ, Flicek P, Getz G, Guigó R, Guo G, Haussler D, Heath S, Hubbard TJ, Jiang T, Jones SM, Li Q, López-Bigas N, Luo R, Muthuswamy L, Ouellette BF, Pearson JV, Puente XS, Quesada V, Raphael BJ, Sander C, Shibata T, Speed TP, Stein LD, Stuart JM, Teague JW, Totoki Y, Tsunoda T, Valencia A, Wheeler DA, Wu H, Zhao S, Zhou G, Stein LD, Guigó R, Hubbard TJ, Joly Y, Jones SM, Kasprzyk A, Lathrop M, López-Bigas N, Ouellette BF, Spellman PT, Teague JW, Thomas G, Valencia A, Yoshida T, Kennedy KL, Axton M, Dyke SO, Futreal PA, Gerhard DS, Gunter C, Guyer M, Hudson TJ, McPherson JD, Miller LJ, Ozenberger B, Shaw KM, Kasprzyk A, Stein LD, Zhang J, Haider SA, Wang J, Yung CK, Cros A, Cross A, Liang Y, Gnaneshan S, Guberman J, Hsu J, Bobrow M, Chalmers DR, Hasel KW, Joly Y, Kaan TS, Kennedy KL, Knoppers BM, Lowrance WW, Masui T, Nicolás P, Rial-Sebbag E, Rodriguez LL, Vergely C, Yoshida T, Grimmond SM, Biankin AV, Bowtell DD, Cloonan N, deFazio A, Eshleman JR, Etemadmoghadam D, Gardiner BB, Gardiner BA, Kench JG, Scarpa A, Sutherland RL, Tempero MA, Waddell NJ, Wilson PJ, McPherson JD, Gallinger S, Tsao MS, Shaw PA, Petersen GM, Mukhopadhyay D, Chin L, DePinho RA, Thayer S, Muthuswamy L, Shazand K, Beck T, Sam M, Timms L, Ballin V, Lu Y, Ji J, Zhang X, Chen F, Hu X, Zhou G, Yang Q, Tian G, Zhang L, Xing X, Li X, Zhu Z, Yu Y, Yu J, Yang H, Lathrop M, Tost J, Brennan P, Holcatova I, Zaridze D, Brazma A, Egevard L, Prokhortchouk E, Banks RE, Uhlén M, Cambon-Thomsen A, Viksna J, Ponten F, Skryabin K, Stratton MR, Futreal PA, Birney E, Borg A, Børresen-Dale AL, Caldas C, Foekens JA, Martin S, Reis-Filho JS, Richardson AL, Sotiriou C, Stunnenberg HG, Thoms G, van de Vijver M, van't Veer L, Calvo F, Birnbaum D, Blanche H, Boucher P, Boyault S, Chabannon C, Gut I, Masson-Jacquemier JD, Lathrop M, Pauporté I, Pivot X, Vincent-Salomon A, Tabone E, Theillet C, Thomas G, Tost J, Treilleux I, Calvo F, Bioulac-Sage P, Clément B, Decaens T, Degos F, Franco D, Gut I, Gut M, Heath S, Lathrop M, Samuel D, Thomas G, Zucman-Rossi J, Lichter P, Eils R, Brors B, Korbel JO, Korshunov A, Landgraf P, Lehrach H, Pfister S, Radlwimmer B, Reifenberger G, Taylor MD, von Kalle C, Majumder PP, Sarin R, Rao TS, Bhan MK, Scarpa A, Pederzoli P, Lawlor RA, Delledonne M, Bardelli A, Biankin AV, Grimmond SM, Gress T, Klimstra D, Zamboni G, Shibata T, Nakamura Y, Nakagawa H, Kusada J, Tsunoda T, Miyano S, Aburatani H, Kato K, Fujimoto A, Yoshida T, Campo E, López-Otín C, Estivill X, Guigó R, de Sanjosé S, Piris MA, Montserrat E, González-Díaz M, Puente XS, Jares P, Valencia A, Himmelbauer H, Himmelbaue H, Quesada V, Bea S, Stratton MR, Futreal PA, Campbell PJ, Vincent-Salomon A, Richardson AL, Reis-Filho JS, van de Vijver M, Thomas G, Masson-Jacquemier JD, Aparicio S, Borg A, Børresen-Dale AL, Caldas C, Foekens JA, Stunnenberg HG, van't Veer L, Easton DF, Spellman PT, Martin S, Barker AD, Chin L, Collins FS, Compton CC, Ferguson ML, Gerhard DS, Getz G, Gunter C, Guttmacher A, Guyer M, Hayes DN, Lander ES, Ozenberger B, Penny R, Peterson J, Sander C, Shaw KM, Speed TP, Spellman PT, Vockley JG, Wheeler DA, Wilson RK, Hudson TJ, Chin L, Knoppers BM, Lander ES, Lichter P, Stein LD, Stratton MR, Anderson W, Barker AD, Bell C, Bobrow M, Burke W, Collins FS, Compton CC, DePinho RA, Easton DF, Futreal PA, Gerhard DS, Green AR, Guyer M, Hamilton SR, Hubbard TJ, Kallioniemi OP, Kennedy KL, Ley TJ, Liu ET, Lu Y, Majumder P, Marra M, Ozenberger B, Peterson J, Schafer AJ, Spellman PT, Stunnenberg HG, Wainwright BJ, Wilson RK, Yang H

Abstract

The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.

MeSH Terms
DNA Methylation DNA Mutational Analysis/trends Databases, Genetic Genes, Neoplasm/genetics Genetics, Medical/organization & administration,trends Genome, Human/genetics Genomics/organization & administration,trends Humans Intellectual Property International Cooperation Mutation Neoplasms/classification,genetics,pathology,therapy
Authors & Affiliations
416 authors, click to expand affiliations / ORCID
International Cancer Genome Consortium
Hudson Thomas J
Anderson Warwick
Artez Axel
Barker Anna D
Bell Cindy
Bernabé Rosa R
Bhan M K
Calvo Fabien
Eerola Iiro
Gerhard Daniela S
Guttmacher Alan
Guyer Mark
Hemsley Fiona M
Jennings Jennifer L
Kerr David
Klatt Peter
Kolar Patrik
Kusada Jun
Lane David P
Laplace Frank
Youyong Lu
Nettekoven Gerd
Ozenberger Brad
Peterson Jane
Rao T S
Remacle Jacques
Schafer Alan J
Shibata Tatsuhiro
Stratton Michael R
Vockley Joseph G
Watanabe Koichi
Yang Huanming
Yuen Matthew M F
Knoppers Bartha M
Bobrow Martin
Cambon-Thomsen Anne
Dressler Lynn G
Dyke Stephanie O M
Joly Yann
Kato Kazuto
Kennedy Karen L
Nicolás Pilar
Parker Michael J
Rial-Sebbag Emmanuelle
Romeo-Casabona Carlos M
Shaw Kenna M
Wallace Susan
Wiesner Georgia L
Zeps Nikolajs
Lichter Peter
Biankin Andrew V
Chabannon Christian
Chin Lynda
Clément Bruno
de Alava Enrique
Degos Françoise
Ferguson Martin L
Geary Peter
Hayes D Neil
Hudson Thomas J
Johns Amber L
Kasprzyk Arek
Nakagawa Hidewaki
Penny Robert
Piris Miguel A
Sarin Rajiv
Scarpa Aldo
Shibata Tatsuhiro
van de Vijver Marc
Futreal P Andrew
Aburatani Hiroyuki
Bayés Mónica
Botwell David D L
Campbell Peter J
Estivill Xavier
Gerhard Daniela S
Grimmond Sean M
Gut Ivo
Hirst Martin
López-Otín Carlos
Majumder Partha
Marra Marco
McPherson John D
Nakagawa Hidewaki
Ning Zemin
Puente Xose S
Ruan Yijun
Shibata Tatsuhiro
Stratton Michael R
Stunnenberg Hendrik G
Swerdlow Harold
Velculescu Victor E
Wilson Richard K
Xue Hong H
Yang Liu
Spellman Paul T
Bader Gary D
Boutros Paul C
Campbell Peter J
Flicek Paul
Getz Gad
Guigó Roderic
Guo Guangwu
Haussler David
Heath Simon
Hubbard Tim J
Jiang Tao
Jones Steven M
Li Qibin
López-Bigas Nuria
Luo Ruibang
Muthuswamy Lakshmi
Ouellette B F Francis
Pearson John V
Puente Xose S
Quesada Victor
Raphael Benjamin J
Sander Chris
Shibata Tatsuhiro
Speed Terence P
Stein Lincoln D
Stuart Joshua M
Teague Jon W
Totoki Yasushi
Tsunoda Tatsuhiko
Valencia Alfonso
Wheeler David A
Wu Honglong
Zhao Shancen
Zhou Guangyu
Stein Lincoln D
Guigó Roderic
Hubbard Tim J
Joly Yann
Jones Steven M
Kasprzyk Arek
Lathrop Mark
López-Bigas Nuria
Ouellette B F Francis
Spellman Paul T
Teague Jon W
Thomas Gilles
Valencia Alfonso
Yoshida Teruhiko
Kennedy Karen L
Axton Myles
Dyke Stephanie O M
Futreal P Andrew
Gerhard Daniela S
Gunter Chris
Guyer Mark
Hudson Thomas J
McPherson John D
Miller Linda J
Ozenberger Brad
Shaw Kenna M
Kasprzyk Arek
Stein Lincoln D
Zhang Junjun
Haider Syed A
Wang Jianxin
Yung Christina K
Cros Anthony
Cross Anthony
Liang Yong
Gnaneshan Saravanamuttu
Guberman Jonathan
Hsu Jack
Bobrow Martin
Chalmers Don R C
Hasel Karl W
Joly Yann
Kaan Terry S H
Kennedy Karen L
Knoppers Bartha M
Lowrance William W
Masui Tohru
Nicolás Pilar
Rial-Sebbag Emmanuelle
Rodriguez Laura Lyman
Vergely Catherine
Yoshida Teruhiko
Grimmond Sean M
Biankin Andrew V
Bowtell David D L
Cloonan Nicole
deFazio Anna
Eshleman James R
Etemadmoghadam Dariush
Gardiner Brooke B
Gardiner Brooke A
Kench James G
Scarpa Aldo
Sutherland Robert L
Tempero Margaret A
Waddell Nicola J
Wilson Peter J
McPherson John D
Gallinger Steve
Tsao Ming-Sound
Shaw Patricia A
Petersen Gloria M
Mukhopadhyay Debabrata
Chin Lynda
DePinho Ronald A
Thayer Sarah
Muthuswamy Lakshmi
Shazand Kamran
Beck Timothy
Sam Michelle
Timms Lee
Ballin Vanessa
Lu Youyong
Ji Jiafu
Zhang Xiuqing
Chen Feng
Hu Xueda
Zhou Guangyu
Yang Qi
Tian Geng
Zhang Lianhai
Xing Xiaofang
Li Xianghong
Zhu Zhenggang
Yu Yingyan
Yu Jun
Yang Huanming
Lathrop Mark
Tost Jörg
Brennan Paul
Holcatova Ivana
Zaridze David
Brazma Alvis
Egevard Lars
Prokhortchouk Egor
Banks Rosamonde Elizabeth
Uhlén Mathias
Cambon-Thomsen Anne
Viksna Juris
Ponten Fredrik
Skryabin Konstantin
Stratton Michael R
Futreal P Andrew
Birney Ewan
Borg Ake
Børresen-Dale Anne-Lise
Caldas Carlos
Foekens John A
Martin Sancha
Reis-Filho Jorge S
Richardson Andrea L
Sotiriou Christos
Stunnenberg Hendrik G
Thoms Giles
van de Vijver Marc
van't Veer Laura
Calvo Fabien
Birnbaum Daniel
Blanche Hélène
Boucher Pascal
Boyault Sandrine
Chabannon Christian
Gut Ivo
Masson-Jacquemier Jocelyne D
Lathrop Mark
Pauporté Iris
Pivot Xavier
Vincent-Salomon Anne
Tabone Eric
Theillet Charles
Thomas Gilles
Tost Jörg
Treilleux Isabelle
Calvo Fabien
Bioulac-Sage Paulette
Clément Bruno
Decaens Thomas
Degos Françoise
Franco Dominique
Gut Ivo
Gut Marta
Heath Simon
Lathrop Mark
Samuel Didier
Thomas Gilles
Zucman-Rossi Jessica
Lichter Peter
Eils Roland
Brors Benedikt
Korbel Jan O
Korshunov Andrey
Landgraf Pablo
Lehrach Hans
Pfister Stefan
Radlwimmer Bernhard
Reifenberger Guido
Taylor Michael D
von Kalle Christof
Majumder Partha P
Sarin Rajiv
Rao T S
Bhan M K
Scarpa Aldo
Pederzoli Paolo
Lawlor Rita A
Delledonne Massimo
Bardelli Alberto
Biankin Andrew V
Grimmond Sean M
Gress Thomas
Klimstra David
Zamboni Giuseppe
Shibata Tatsuhiro
Nakamura Yusuke
Nakagawa Hidewaki
Kusada Jun
Tsunoda Tatsuhiko
Miyano Satoru
Aburatani Hiroyuki
Kato Kazuto
Fujimoto Akihiro
Yoshida Teruhiko
Campo Elias
López-Otín Carlos
Estivill Xavier
Guigó Roderic
de Sanjosé Silvia
Piris Miguel A
Montserrat Emili
González-Díaz Marcos
Puente Xose S
Jares Pedro
Valencia Alfonso
Himmelbauer Heinz
Himmelbaue Heinz
Quesada Victor
Bea Silvia
Stratton Michael R
Futreal P Andrew
Campbell Peter J
Vincent-Salomon Anne
Richardson Andrea L
Reis-Filho Jorge S
van de Vijver Marc
Thomas Gilles
Masson-Jacquemier Jocelyne D
Aparicio Samuel
Borg Ake
Børresen-Dale Anne-Lise
Caldas Carlos
Foekens John A
Stunnenberg Hendrik G
van't Veer Laura
Easton Douglas F
Spellman Paul T
Martin Sancha
Barker Anna D
Chin Lynda
Collins Francis S
Compton Carolyn C
Ferguson Martin L
Gerhard Daniela S
Getz Gad
Gunter Chris
Guttmacher Alan
Guyer Mark
Hayes D Neil
Lander Eric S
Ozenberger Brad
Penny Robert
Peterson Jane
Sander Chris
Shaw Kenna M
Speed Terence P
Spellman Paul T
Vockley Joseph G
Wheeler David A
Wilson Richard K
Hudson Thomas J
Chin Lynda
Knoppers Bartha M
Lander Eric S
Lichter Peter
Stein Lincoln D
Stratton Michael R
Anderson Warwick
Barker Anna D
Bell Cindy
Bobrow Martin
Burke Wylie
Collins Francis S
Compton Carolyn C
DePinho Ronald A
Easton Douglas F
Futreal P Andrew
Gerhard Daniela S
Green Anthony R
Guyer Mark
Hamilton Stanley R
Hubbard Tim J
Kallioniemi Olli P
Kennedy Karen L
Ley Timothy J
Liu Edison T
Lu Youyong
Majumder Partha
Marra Marco
Ozenberger Brad
Peterson Jane
Schafer Alan J
Spellman Paul T
Stunnenberg Hendrik G
Wainwright Brandon J
Wilson Richard K
Yang Huanming
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
Published
2010-04-15
Pages
993-8
Language
English
Region
England
NLM ID
0410462
PMCID
PMC2902243
Subset
IM
Grants
NCI NIH HHS · P50 CA127003-05 · United States
NCI NIH HHS · P50 CA102701-08 · United States
NHGRI NIH HHS · R01 HG001806-02 · United States
NCI NIH HHS · P01 CA117969 · United States
NIDDK NIH HHS · K08 DK071329 · United States
Wellcome Trust · 088340 · United Kingdom
NIDDK NIH HHS · K08 DK071329-04 · United States
Wellcome Trust · 077198 · United Kingdom
NCI NIH HHS · P50 CA127003 · United States
NCI NIH HHS · P01 CA117969-05 · United States
NCI NIH HHS · P01 CA117969-04S1 · United States
NIDDK NIH HHS · K08 DK071329-05 · United States
NCI NIH HHS · P50 CA127003-04 · United States
Wellcome Trust · 093867 · United Kingdom
NCI NIH HHS · P50 CA102701 · United States
NCI NIH HHS · R21 CA094510 · United States
Corrections
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