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PMID: 23416462 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway.

Cellular signalling ·Vol. 25 ·No. 5 ·2013-05-00 ·Pages 1086-95

Wan G, Mathur R, Hu X, Liu Y, Zhang X, Peng G, Lu X

Abstract

The maintenance of genome integrity is essential for the proper function and survival of all organisms. Human cells have evolved prompt and efficient DNA damage response to eliminate the detrimental effects of DNA lesions. The DNA damage response involves a complex network of processes that detect and repair DNA damage, in which long non-coding RNAs (lncRNAs), a new class of regulatory RNAs, may play important roles. Recent studies have identified a large number of lncRNAs in mammalian transcriptomes. However, little is known about the regulation and function of lncRNAs in the DNA damage response. In the present study, we demonstrate that one specific lncRNA, ANRIL, is transcriptionally up-regulated by the transcription factor E2F1 in an ATM-dependent manner following DNA damage, and elevated levels of ANRIL suppress the expression of INK4a, INK4b and ARF at the late-stage of DNA damage response, allowing the cell to return to normal at the completion of the DNA repair.

MeSH Terms
ADP-Ribosylation Factors/genetics,metabolism Apoptosis Ataxia Telangiectasia Mutated Proteins Cell Cycle Checkpoints Cell Cycle Proteins/metabolism Cell Line Cyclin-Dependent Kinase Inhibitor p15/genetics,metabolism Cyclin-Dependent Kinase Inhibitor p16/genetics,metabolism DNA Damage DNA Repair DNA-Binding Proteins/metabolism E2F1 Transcription Factor/genetics,metabolism Genetic Loci Humans Protein Serine-Threonine Kinases/metabolism RNA, Long Noncoding/metabolism Signal Transduction Tumor Suppressor Proteins/metabolism Up-Regulation
Chemicals
CDKN2B antisense RNA, human Cell Cycle Proteins Cyclin-Dependent Kinase Inhibitor p15 Cyclin-Dependent Kinase Inhibitor p16 DNA-Binding Proteins E2F1 Transcription Factor RNA, Long Noncoding Tumor Suppressor Proteins ATM protein, human Ataxia Telangiectasia Mutated Proteins Protein Serine-Threonine Kinases ADP-Ribosylation Factors
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Wan Guohui
Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Mathur Rohit
Hu Xiaoxiao
Liu Yunhua
Zhang Xinna
Peng Guang
Lu Xiongbin
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46 references, click to expand
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Article Info
Journal
Cellular signalling
Abbr.
Cell Signal
ISSN
1873-3913
DOI
10.1016/j.cellsig.2013.02.006
Published
2013-05-00
Epub
2013-00-14
Pages
1086-95
Language
English
Region
England
NLM ID
8904683
PMCID
PMC3675781
Subset
IM
Grants
NCI NIH HHS · R01 CA136549 · United States
NCI NIH HHS · R03 CA142605 · United States
NCI NIH HHS · R01CA136549 · United States
NCI NIH HHS · R03CA142605 · United States
External Links
PubMed source DOI: 10.1016/j.cellsig.2013.02.006 PMC Full Text View journal details
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