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PMID: 22337053 Published · epublish English Journal Article Review

Modular regulatory principles of large non-coding RNAs.

Nature ·Vol. 482 ·No. 7385 ·2012-02-15 ·Pages 339-46

Guttman M, Rinn JL

Abstract

It is clear that RNA has a diverse set of functions and is more than just a messenger between gene and protein. The mammalian genome is extensively transcribed, giving rise to thousands of non-coding transcripts. Whether all of these transcripts are functional is debated, but it is evident that there are many functional large non-coding RNAs (ncRNAs). Recent studies have begun to explore the functional diversity and mechanistic role of these large ncRNAs. Here we synthesize these studies to provide an emerging model whereby large ncRNAs might achieve regulatory specificity through modularity, assembling diverse combinations of proteins and possibly RNA and DNA interactions.

MeSH Terms
Chromatin/genetics Gene Expression Regulation RNA, Untranslated/analysis,genetics,metabolism RNA-Binding Proteins/metabolism
Chemicals
Chromatin RNA, Untranslated RNA-Binding Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Guttman Mitchell
Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA. mguttman@mit.edu
Rinn John L
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature10887
Email
mguttman@mit.edu
Published
2012-02-15
Epub
2012-00-15
Pages
339-46
Language
English
Region
England
NLM ID
0410462
PMCID
PMC4197003
Subset
IM
Grants
NIGMS NIH HHS · P01 GM099117 · United States
NIEHS NIH HHS · R01 ES020260 · United States
External Links
PubMed source DOI: 10.1038/nature10887 PMC Full Text View journal details
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